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Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma

OBJECTIVE: This study is aimed at analyzing the factors affecting the recurrence patterns and recurrence-free survival (RFS) of high-grade gliomas (HGG). METHODS: Eligible patients admitted to the Affiliated Hospital of Xuzhou Medical University were selected. Subsequently, the effects of some clini...

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Autores principales: Chen, Jie, Qiu, Hui, Chen, Rui, Huang, Jiani, Chen, Liang, Wan, Juncheng, Chen, Qi, Zhang, Longzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348930/
https://www.ncbi.nlm.nih.gov/pubmed/35936378
http://dx.doi.org/10.1155/2022/9547166
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author Chen, Jie
Qiu, Hui
Chen, Rui
Huang, Jiani
Chen, Liang
Wan, Juncheng
Chen, Qi
Zhang, Longzhen
author_facet Chen, Jie
Qiu, Hui
Chen, Rui
Huang, Jiani
Chen, Liang
Wan, Juncheng
Chen, Qi
Zhang, Longzhen
author_sort Chen, Jie
collection PubMed
description OBJECTIVE: This study is aimed at analyzing the factors affecting the recurrence patterns and recurrence-free survival (RFS) of high-grade gliomas (HGG). METHODS: Eligible patients admitted to the Affiliated Hospital of Xuzhou Medical University were selected. Subsequently, the effects of some clinical data including age, gender, WHO pathological grades, tumor site, tumor size, clinical treatments, and peritumoral edema (PTE) area and molecular markers (Ki-67, MGMT, IDH-1, and p53) on HGG patients' recurrence patterns and RFS were analyzed. RESULTS: A total number of 77 patients were enrolled into this study. After analyzing all the cases, it was determined that tumor size and tumor site had a significant influence on the recurrent patterns of HGG, and PTE was an independent predict factor of recurrence patterns. Specifically, when the PTE was mild (<1 cm), the recurrence pattern tended to be local; in contrast, HGG was more likely to progress to marginal recurrence and distant recurrence. Furthermore, age and PTE were significantly associated with RFS; the median RFS of the population with PTE < 1 cm (23.60 months) was obviously longer than the population with PTE ≥ 1 cm (5.00 months). CONCLUSIONS: PTE is an independent predictor of recurrence patterns and RFS for HGG. Therefore, preoperative identification of PTE in HGG patients is crucially important, which is helpful to accurately estimate the recurrence pattern and RFS.
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spelling pubmed-93489302022-08-04 Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma Chen, Jie Qiu, Hui Chen, Rui Huang, Jiani Chen, Liang Wan, Juncheng Chen, Qi Zhang, Longzhen Comput Math Methods Med Research Article OBJECTIVE: This study is aimed at analyzing the factors affecting the recurrence patterns and recurrence-free survival (RFS) of high-grade gliomas (HGG). METHODS: Eligible patients admitted to the Affiliated Hospital of Xuzhou Medical University were selected. Subsequently, the effects of some clinical data including age, gender, WHO pathological grades, tumor site, tumor size, clinical treatments, and peritumoral edema (PTE) area and molecular markers (Ki-67, MGMT, IDH-1, and p53) on HGG patients' recurrence patterns and RFS were analyzed. RESULTS: A total number of 77 patients were enrolled into this study. After analyzing all the cases, it was determined that tumor size and tumor site had a significant influence on the recurrent patterns of HGG, and PTE was an independent predict factor of recurrence patterns. Specifically, when the PTE was mild (<1 cm), the recurrence pattern tended to be local; in contrast, HGG was more likely to progress to marginal recurrence and distant recurrence. Furthermore, age and PTE were significantly associated with RFS; the median RFS of the population with PTE < 1 cm (23.60 months) was obviously longer than the population with PTE ≥ 1 cm (5.00 months). CONCLUSIONS: PTE is an independent predictor of recurrence patterns and RFS for HGG. Therefore, preoperative identification of PTE in HGG patients is crucially important, which is helpful to accurately estimate the recurrence pattern and RFS. Hindawi 2022-07-27 /pmc/articles/PMC9348930/ /pubmed/35936378 http://dx.doi.org/10.1155/2022/9547166 Text en Copyright © 2022 Jie Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Jie
Qiu, Hui
Chen, Rui
Huang, Jiani
Chen, Liang
Wan, Juncheng
Chen, Qi
Zhang, Longzhen
Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma
title Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma
title_full Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma
title_fullStr Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma
title_full_unstemmed Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma
title_short Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma
title_sort peritumor edema serves as an independent predictive factor of recurrence patterns and recurrence-free survival for high-grade glioma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348930/
https://www.ncbi.nlm.nih.gov/pubmed/35936378
http://dx.doi.org/10.1155/2022/9547166
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