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Decoding molecular factors shaping human angiotensin converting enzyme 2 receptor usage by spike glycoprotein in lineage B beta-coronaviruses

Acquiring the human ACE2 receptor usage trait enables the coronaviruses to spill over to humans. However, the origin of the ACE2 usage trait in coronaviruses is poorly understood. Using a multi-disciplinary approach combining evolutionary bioinformatics and molecular dynamics simulation, we decode t...

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Detalles Bibliográficos
Autores principales: Chakraborty, Sandipan, Ghosh, Sanjana, Mondal, Trisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349031/
https://www.ncbi.nlm.nih.gov/pubmed/35932890
http://dx.doi.org/10.1016/j.bbadis.2022.166514