Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

BACKGROUND: In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodies. Within weeks of the first report of B.1.1.529, this VoC...

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Detalles Bibliográficos
Autores principales: Hawman, David W., Meade-White, Kimberly, Clancy, Chad, Archer, Jacob, Hinkley, Troy, Leventhal, Shanna S., Rao, Deepashri, Stamper, Allie, Lewis, Matthew, Rosenke, Rebecca, Krieger, Kyle, Randall, Samantha, Khandhar, Amit P., Hao, Linhue, Hsiang, Tien-Ying, Greninger, Alexander L., Gale, Michael, Berglund, Peter, Fuller, Deborah Heydenburg, Rosenke, Kyle, Feldmann, Heinz, Erasmus, Jesse H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349033/
https://www.ncbi.nlm.nih.gov/pubmed/35932641
http://dx.doi.org/10.1016/j.ebiom.2022.104196

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