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Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests reveal...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349096/ https://www.ncbi.nlm.nih.gov/pubmed/34505185 http://dx.doi.org/10.1007/s10803-021-05271-7 |
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| author | Casey, S. Carter, M. Looney, A. M. Livingstone, V. Moloney, G. O’Keeffe, G. W. Taylor, R. S. Kenny, L. C. McCarthy, F. P. McCowan, L. M. E. Thompson, J. M. D. Murray, D. M. |
| author_facet | Casey, S. Carter, M. Looney, A. M. Livingstone, V. Moloney, G. O’Keeffe, G. W. Taylor, R. S. Kenny, L. C. McCarthy, F. P. McCowan, L. M. E. Thompson, J. M. D. Murray, D. M. |
| author_sort | Casey, S. |
| collection | PubMed |
| description | Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. |
| format | Online Article Text |
| id | pubmed-9349096 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Springer US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93490962022-08-05 Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Casey, S. Carter, M. Looney, A. M. Livingstone, V. Moloney, G. O’Keeffe, G. W. Taylor, R. S. Kenny, L. C. McCarthy, F. P. McCowan, L. M. E. Thompson, J. M. D. Murray, D. M. J Autism Dev Disord Original Paper Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. Springer US 2021-09-09 2022 /pmc/articles/PMC9349096/ /pubmed/34505185 http://dx.doi.org/10.1007/s10803-021-05271-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Original Paper Casey, S. Carter, M. Looney, A. M. Livingstone, V. Moloney, G. O’Keeffe, G. W. Taylor, R. S. Kenny, L. C. McCarthy, F. P. McCowan, L. M. E. Thompson, J. M. D. Murray, D. M. Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder |
| title | Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder |
| title_full | Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder |
| title_fullStr | Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder |
| title_full_unstemmed | Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder |
| title_short | Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder |
| title_sort | maternal mid-gestation cytokine dysregulation in mothers of children with autism spectrum disorder |
| topic | Original Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349096/ https://www.ncbi.nlm.nih.gov/pubmed/34505185 http://dx.doi.org/10.1007/s10803-021-05271-7 |
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