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Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease
BACKGROUND: Arylsulfatase A (ARSA), a lysosomal enzyme, has been shown to inhibit the aggregation and propagation of α-synuclein (α-syn) through its molecular chaperone function. The relationship between ARSA levels and Parkinson’s disease (PD) in the Chinese Han population remains controversial, an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349122/ https://www.ncbi.nlm.nih.gov/pubmed/35486332 http://dx.doi.org/10.1007/s10072-022-06093-w |
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author | Li, Mingjian Shi, Xiaoxue Ma, Jianjun Sun, Wenhua Wang, Zhidong Li, Dongsheng Zheng, Jinhua Zhao, Zhenxiang Gu, Qi Chen, Siyuan |
author_facet | Li, Mingjian Shi, Xiaoxue Ma, Jianjun Sun, Wenhua Wang, Zhidong Li, Dongsheng Zheng, Jinhua Zhao, Zhenxiang Gu, Qi Chen, Siyuan |
author_sort | Li, Mingjian |
collection | PubMed |
description | BACKGROUND: Arylsulfatase A (ARSA), a lysosomal enzyme, has been shown to inhibit the aggregation and propagation of α-synuclein (α-syn) through its molecular chaperone function. The relationship between ARSA levels and Parkinson’s disease (PD) in the Chinese Han population remains controversial, and few quantitative research studies have investigated the relationship between plasma ARSA levels and PD. OBJECTIVES: The purpose of this study was to investigate the relationships between ARSA levels and cognitive function in PD patients and to evaluate the association of ARSA and α-syn levels with nonmotor symptoms. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma ARSA and α-syn levels in 50 healthy controls, 120 PD patients (61 PD patients with no cognitive impairment (PD-NCI) and 59 PD patients with cognitive impairment (PD-CI)). Motor symptoms and nonmotor symptoms (cognitive function, Unified Parkinson’s Disease Rating Scale (UPDRS) score, depression, anxiety, constipation, olfactory dysfunction, sleep disruption, and other symptoms) were assessed with the relevant scales. The Kruskal–Wallis H test was used for comparison between groups, and Pearson/Spearman analysis was used for correlation analysis. RESULTS: The plasma ARSA concentrations were lower in the PD-CI group than in the PD-NCI group. The plasma α-syn levels in the PD-CI group were higher than those in the healthy control group, and the plasma ARSA levels were correlated with the Mini-Mental State Examination (MMSE scores) and Hoehn and Yahr (H-Y) stage. CONCLUSION: We used a quantitative assessment method to show that low plasma ARSA levels and high α-syn levels are related to cognitive impairment in PD patients. Plasma ARSA levels gradually decrease with PD progression. |
format | Online Article Text |
id | pubmed-9349122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-93491222022-08-05 Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease Li, Mingjian Shi, Xiaoxue Ma, Jianjun Sun, Wenhua Wang, Zhidong Li, Dongsheng Zheng, Jinhua Zhao, Zhenxiang Gu, Qi Chen, Siyuan Neurol Sci Original Article BACKGROUND: Arylsulfatase A (ARSA), a lysosomal enzyme, has been shown to inhibit the aggregation and propagation of α-synuclein (α-syn) through its molecular chaperone function. The relationship between ARSA levels and Parkinson’s disease (PD) in the Chinese Han population remains controversial, and few quantitative research studies have investigated the relationship between plasma ARSA levels and PD. OBJECTIVES: The purpose of this study was to investigate the relationships between ARSA levels and cognitive function in PD patients and to evaluate the association of ARSA and α-syn levels with nonmotor symptoms. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma ARSA and α-syn levels in 50 healthy controls, 120 PD patients (61 PD patients with no cognitive impairment (PD-NCI) and 59 PD patients with cognitive impairment (PD-CI)). Motor symptoms and nonmotor symptoms (cognitive function, Unified Parkinson’s Disease Rating Scale (UPDRS) score, depression, anxiety, constipation, olfactory dysfunction, sleep disruption, and other symptoms) were assessed with the relevant scales. The Kruskal–Wallis H test was used for comparison between groups, and Pearson/Spearman analysis was used for correlation analysis. RESULTS: The plasma ARSA concentrations were lower in the PD-CI group than in the PD-NCI group. The plasma α-syn levels in the PD-CI group were higher than those in the healthy control group, and the plasma ARSA levels were correlated with the Mini-Mental State Examination (MMSE scores) and Hoehn and Yahr (H-Y) stage. CONCLUSION: We used a quantitative assessment method to show that low plasma ARSA levels and high α-syn levels are related to cognitive impairment in PD patients. Plasma ARSA levels gradually decrease with PD progression. Springer International Publishing 2022-04-29 2022 /pmc/articles/PMC9349122/ /pubmed/35486332 http://dx.doi.org/10.1007/s10072-022-06093-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Li, Mingjian Shi, Xiaoxue Ma, Jianjun Sun, Wenhua Wang, Zhidong Li, Dongsheng Zheng, Jinhua Zhao, Zhenxiang Gu, Qi Chen, Siyuan Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease |
title | Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease |
title_full | Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease |
title_fullStr | Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease |
title_full_unstemmed | Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease |
title_short | Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease |
title_sort | plasma arylsulfatase a levels are associated with cognitive function in parkinson’s disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349122/ https://www.ncbi.nlm.nih.gov/pubmed/35486332 http://dx.doi.org/10.1007/s10072-022-06093-w |
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