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R132H IDH1 sensitizes glioma to the antiproliferative and cytotoxic effects of BET inhibition

INTRODUCTION: Mutations in isocitrate dehydrogenase 1/2 (IDH(mut)) identify a subset of gliomas that exhibit epigenetic dysregulation via aberrant DNA methylation. These tumors are ultimately fatal and lack effective therapeutic strategies. Considering the epigenetic dysregulation of IDH(mut) glioma...

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Detalles Bibliográficos
Autores principales:	Sears, Thomas K., Woolard, Kevin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Article – Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349147/ https://www.ncbi.nlm.nih.gov/pubmed/35467128 http://dx.doi.org/10.1007/s00432-022-04018-w

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