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Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes
Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes, high levels of DNA methylation occur exclusively in the transcriptionally active regions, with moderate to low levels of methylat...
Autores principales: | Yano, Seiichi, Ishiuchi, Takashi, Abe, Shusaku, Namekawa, Satoshi H., Huang, Gang, Ogawa, Yoshihiro, Sasaki, Hiroyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349174/ https://www.ncbi.nlm.nih.gov/pubmed/35922445 http://dx.doi.org/10.1038/s41467-022-32141-2 |
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