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Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation

Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds. The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and...

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Detalles Bibliográficos
Autores principales:	Müller, Claudia Damaris, Ruiz-Gómez, Gloria, Cazzonelli, Sophie, Möller, Stephanie, Wodtke, Robert, Löser, Reik, Freyse, Joanna, Dürig, Jan-Niklas, Rademann, Jörg, Hempel, Ute, Pisabarro, M. Teresa, Vogel, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349199/ https://www.ncbi.nlm.nih.gov/pubmed/35922533 http://dx.doi.org/10.1038/s41598-022-17113-2

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