Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal control is necessary. We report the development of an implantable mechanother...

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Detalles Bibliográficos
Autores principales: Whyte, William, Goswami, Debkalpa, Wang, Sophie X., Fan, Yiling, Ward, Niamh A., Levey, Ruth E., Beatty, Rachel, Robinson, Scott T., Sheppard, Declan, O’Connor, Raymond, Monahan, David S., Trask, Lesley, Mendez, Keegan L., Varela, Claudia E., Horvath, Markus A., Wylie, Robert, O’Dwyer, Joanne, Domingo-Lopez, Daniel A., Rothman, Arielle S., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349266/
https://www.ncbi.nlm.nih.gov/pubmed/35922421
http://dx.doi.org/10.1038/s41467-022-32147-w

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