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A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer
Six members of the gasdermin family are involved in various biological functions in malignant tumors. The present study aimed to perform a comprehensive analysis of gasdermin family genes in pan-cancer. Raw data was acquired from the genotype-tissue expression (GTEx) and the Cancer Genome Atlas. Hig...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349317/ https://www.ncbi.nlm.nih.gov/pubmed/35922531 http://dx.doi.org/10.1038/s41598-022-17100-7 |
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author | Huo, Cheng-Long Deng, Yan Sun, Zhen-Gang |
author_facet | Huo, Cheng-Long Deng, Yan Sun, Zhen-Gang |
author_sort | Huo, Cheng-Long |
collection | PubMed |
description | Six members of the gasdermin family are involved in various biological functions in malignant tumors. The present study aimed to perform a comprehensive analysis of gasdermin family genes in pan-cancer. Raw data was acquired from the genotype-tissue expression (GTEx) and the Cancer Genome Atlas. High inter-tumor heterogeneity in the expression between paracancerous and tumor tissues was observed across cancers. Survival analysis confirmed that the risk or protective effects of gasdermin family members on prognosis depended on the cancer types. The mutation frequency appeared to be high, and the mutation group had a worse prognosis. Besides, gasdermin family genes were associated with immune infiltrate subtypes, stromal and immune cell infiltration levels, TMB, MSI, immune checkpoint gene expression, and tumor stemness scores. Moreover, gasdermin family gene expressions affected the expressions of MMR genes and methyltransferases and could predict cancer cells sensitivity to chemotherapeutic drugs. Subsequently, the findings were double-checked in LIHC and PAAD. GSEA results indicated the gasdermin family genes mainly involved in tumor metabolism and immune microenvironment remodeling related signaling pathways. In conclusion, our findings confirmed that gasdermin family genes were potential therapeutic cancer targets in pan-cancer. |
format | Online Article Text |
id | pubmed-9349317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93493172022-08-05 A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer Huo, Cheng-Long Deng, Yan Sun, Zhen-Gang Sci Rep Article Six members of the gasdermin family are involved in various biological functions in malignant tumors. The present study aimed to perform a comprehensive analysis of gasdermin family genes in pan-cancer. Raw data was acquired from the genotype-tissue expression (GTEx) and the Cancer Genome Atlas. High inter-tumor heterogeneity in the expression between paracancerous and tumor tissues was observed across cancers. Survival analysis confirmed that the risk or protective effects of gasdermin family members on prognosis depended on the cancer types. The mutation frequency appeared to be high, and the mutation group had a worse prognosis. Besides, gasdermin family genes were associated with immune infiltrate subtypes, stromal and immune cell infiltration levels, TMB, MSI, immune checkpoint gene expression, and tumor stemness scores. Moreover, gasdermin family gene expressions affected the expressions of MMR genes and methyltransferases and could predict cancer cells sensitivity to chemotherapeutic drugs. Subsequently, the findings were double-checked in LIHC and PAAD. GSEA results indicated the gasdermin family genes mainly involved in tumor metabolism and immune microenvironment remodeling related signaling pathways. In conclusion, our findings confirmed that gasdermin family genes were potential therapeutic cancer targets in pan-cancer. Nature Publishing Group UK 2022-08-03 /pmc/articles/PMC9349317/ /pubmed/35922531 http://dx.doi.org/10.1038/s41598-022-17100-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Huo, Cheng-Long Deng, Yan Sun, Zhen-Gang A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
title | A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
title_full | A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
title_fullStr | A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
title_full_unstemmed | A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
title_short | A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
title_sort | comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349317/ https://www.ncbi.nlm.nih.gov/pubmed/35922531 http://dx.doi.org/10.1038/s41598-022-17100-7 |
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