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Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort
Early kinetics of SARS‐CoV‐2 viral load (VL) in plasma determined by quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single‐...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349374/ https://www.ncbi.nlm.nih.gov/pubmed/35811284 http://dx.doi.org/10.1002/jmv.27989 |
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author | Cardeñoso Domingo, Laura Roy Vallejo, Emilia Zurita Cruz, Nelly D. Chicot Llano, Marta Ávalos Pérez‐Urria, Elena Barrios, Ana Hernando Santos, Julia Ortiz, Javier Rodríguez García, Sebastián C. Martín Ramírez, Alexandra Ciudad Sañudo, Marianela Marcos, Celeste García Castillo, Elena Fontán García‐Rodrigo, Leticia González, Begoña Méndez, Rosa Iturrate, Isabel Sanz García, Ancor Villa, Almudena Sánchez Azofra, Ana Quicios, Begoña Arribas, David Álvarez Rodríguez, Jesús Patiño, Pablo Trigueros, Marina Uriarte, Miren Triguero Martínez, Ana Arévalo, Cristina Galván Román, José M. García‐Vicuña, Rosario Ancochea, Julio Soriano, Joan B. Canabal, Alfonso Muñoz Calleja, Cecilia De la Cámara, Rafael Suarez Fernández, Carmen González Álvaro, Isidoro Rodríguez‐Serrano, Diego A. |
author_facet | Cardeñoso Domingo, Laura Roy Vallejo, Emilia Zurita Cruz, Nelly D. Chicot Llano, Marta Ávalos Pérez‐Urria, Elena Barrios, Ana Hernando Santos, Julia Ortiz, Javier Rodríguez García, Sebastián C. Martín Ramírez, Alexandra Ciudad Sañudo, Marianela Marcos, Celeste García Castillo, Elena Fontán García‐Rodrigo, Leticia González, Begoña Méndez, Rosa Iturrate, Isabel Sanz García, Ancor Villa, Almudena Sánchez Azofra, Ana Quicios, Begoña Arribas, David Álvarez Rodríguez, Jesús Patiño, Pablo Trigueros, Marina Uriarte, Miren Triguero Martínez, Ana Arévalo, Cristina Galván Román, José M. García‐Vicuña, Rosario Ancochea, Julio Soriano, Joan B. Canabal, Alfonso Muñoz Calleja, Cecilia De la Cámara, Rafael Suarez Fernández, Carmen González Álvaro, Isidoro Rodríguez‐Serrano, Diego A. |
author_sort | Cardeñoso Domingo, Laura |
collection | PubMed |
description | Early kinetics of SARS‐CoV‐2 viral load (VL) in plasma determined by quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single‐center study including consecutive adult patients hospitalized with COVID‐19 between November 2020 and January 2021. Serial plasma samples were obtained until discharge. Quantitative RT‐PCR was performed to assess SARS‐CoV‐2 VL. The main outcomes were in‐hospital mortality, admission to the Intensive Care Unit (ICU), and their combination (Poor Outcome). Relevant viremia (RV), established in the prospective study, was assessed in a retrospective cohort including hospitalized COVID‐19 patients from April 2021 to May 2022, in which plasma samples were collected according to clinical criteria. Prospective cohort: 57 patients were included. RV was defined as at least a twofold increase in VL within ≤2 days or a VL > 300 copies/ml, in the first week. Patients with RV (N = 14; 24.6%) were more likely to die than those without RV (35.7% vs. 0%), needed ICU admission (57% vs. 0%) or had Poor Outcome (71.4% vs. 0%), (p < 0.001 for the three variables). Retrospective cohort: 326 patients were included, 18.7% presented RV. Patients with RV compared with patients without RV had higher rates of ICU‐admission (odds ratio [OR]: 5.6 [95% confidence interval [CI]: 2.1–15.1); p = 0.001), mortality (OR: 13.5 [95% CI: 6.3–28.7]; p < 0.0001) and Poor Outcome (OR: 11.2 [95% CI: 5.8–22]; p < 0.0001). Relevant SARS‐CoV‐2 viremia in the first week of hospitalization was associated with higher in‐hospital mortality, ICU admission, and Poor Outcome. Findings observed in the prospective cohort were confirmed in a larger validation cohort. |
format | Online Article Text |
id | pubmed-9349374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93493742022-08-04 Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort Cardeñoso Domingo, Laura Roy Vallejo, Emilia Zurita Cruz, Nelly D. Chicot Llano, Marta Ávalos Pérez‐Urria, Elena Barrios, Ana Hernando Santos, Julia Ortiz, Javier Rodríguez García, Sebastián C. Martín Ramírez, Alexandra Ciudad Sañudo, Marianela Marcos, Celeste García Castillo, Elena Fontán García‐Rodrigo, Leticia González, Begoña Méndez, Rosa Iturrate, Isabel Sanz García, Ancor Villa, Almudena Sánchez Azofra, Ana Quicios, Begoña Arribas, David Álvarez Rodríguez, Jesús Patiño, Pablo Trigueros, Marina Uriarte, Miren Triguero Martínez, Ana Arévalo, Cristina Galván Román, José M. García‐Vicuña, Rosario Ancochea, Julio Soriano, Joan B. Canabal, Alfonso Muñoz Calleja, Cecilia De la Cámara, Rafael Suarez Fernández, Carmen González Álvaro, Isidoro Rodríguez‐Serrano, Diego A. J Med Virol Research Articles Early kinetics of SARS‐CoV‐2 viral load (VL) in plasma determined by quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single‐center study including consecutive adult patients hospitalized with COVID‐19 between November 2020 and January 2021. Serial plasma samples were obtained until discharge. Quantitative RT‐PCR was performed to assess SARS‐CoV‐2 VL. The main outcomes were in‐hospital mortality, admission to the Intensive Care Unit (ICU), and their combination (Poor Outcome). Relevant viremia (RV), established in the prospective study, was assessed in a retrospective cohort including hospitalized COVID‐19 patients from April 2021 to May 2022, in which plasma samples were collected according to clinical criteria. Prospective cohort: 57 patients were included. RV was defined as at least a twofold increase in VL within ≤2 days or a VL > 300 copies/ml, in the first week. Patients with RV (N = 14; 24.6%) were more likely to die than those without RV (35.7% vs. 0%), needed ICU admission (57% vs. 0%) or had Poor Outcome (71.4% vs. 0%), (p < 0.001 for the three variables). Retrospective cohort: 326 patients were included, 18.7% presented RV. Patients with RV compared with patients without RV had higher rates of ICU‐admission (odds ratio [OR]: 5.6 [95% confidence interval [CI]: 2.1–15.1); p = 0.001), mortality (OR: 13.5 [95% CI: 6.3–28.7]; p < 0.0001) and Poor Outcome (OR: 11.2 [95% CI: 5.8–22]; p < 0.0001). Relevant SARS‐CoV‐2 viremia in the first week of hospitalization was associated with higher in‐hospital mortality, ICU admission, and Poor Outcome. Findings observed in the prospective cohort were confirmed in a larger validation cohort. John Wiley and Sons Inc. 2022-08-09 2022-11 /pmc/articles/PMC9349374/ /pubmed/35811284 http://dx.doi.org/10.1002/jmv.27989 Text en © 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Cardeñoso Domingo, Laura Roy Vallejo, Emilia Zurita Cruz, Nelly D. Chicot Llano, Marta Ávalos Pérez‐Urria, Elena Barrios, Ana Hernando Santos, Julia Ortiz, Javier Rodríguez García, Sebastián C. Martín Ramírez, Alexandra Ciudad Sañudo, Marianela Marcos, Celeste García Castillo, Elena Fontán García‐Rodrigo, Leticia González, Begoña Méndez, Rosa Iturrate, Isabel Sanz García, Ancor Villa, Almudena Sánchez Azofra, Ana Quicios, Begoña Arribas, David Álvarez Rodríguez, Jesús Patiño, Pablo Trigueros, Marina Uriarte, Miren Triguero Martínez, Ana Arévalo, Cristina Galván Román, José M. García‐Vicuña, Rosario Ancochea, Julio Soriano, Joan B. Canabal, Alfonso Muñoz Calleja, Cecilia De la Cámara, Rafael Suarez Fernández, Carmen González Álvaro, Isidoro Rodríguez‐Serrano, Diego A. Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort |
title | Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort |
title_full | Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort |
title_fullStr | Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort |
title_full_unstemmed | Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort |
title_short | Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort |
title_sort | relevant sars‐cov‐2 viremia is associated with covid‐19 severity: prospective cohort study and validation cohort |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349374/ https://www.ncbi.nlm.nih.gov/pubmed/35811284 http://dx.doi.org/10.1002/jmv.27989 |
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