Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination

Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complemen...

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Detalles Bibliográficos
Autores principales: Misawa, Kyohei, Yasuda, Hajime, Koyama, Daisuke, Inano, Tadaaki, Inoguchi, Akemi, Shirasu, Chinami, Takano, Hina, Iwao, Noriaki, Ando, Miki, Koike, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349421/
https://www.ncbi.nlm.nih.gov/pubmed/35941885
http://dx.doi.org/10.1002/jha2.508
Descripción
Sumario:Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complement‐mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA and immune thrombocytopenia have been reported to develop following the mRNA COVID‐19 vaccination. However, PCH developing subsequent to mRNA vaccination has never been reported. We report a 59‐year‐old male who developed PCH approximately a month after his second mRNA COVID‐19 vaccination.

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