Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination

Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complemen...

Descripción completa

Detalles Bibliográficos
Autores principales: Misawa, Kyohei, Yasuda, Hajime, Koyama, Daisuke, Inano, Tadaaki, Inoguchi, Akemi, Shirasu, Chinami, Takano, Hina, Iwao, Noriaki, Ando, Miki, Koike, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349421/
https://www.ncbi.nlm.nih.gov/pubmed/35941885
http://dx.doi.org/10.1002/jha2.508
_version_ 1784762119361658880
author Misawa, Kyohei
Yasuda, Hajime
Koyama, Daisuke
Inano, Tadaaki
Inoguchi, Akemi
Shirasu, Chinami
Takano, Hina
Iwao, Noriaki
Ando, Miki
Koike, Michiaki
author_facet Misawa, Kyohei
Yasuda, Hajime
Koyama, Daisuke
Inano, Tadaaki
Inoguchi, Akemi
Shirasu, Chinami
Takano, Hina
Iwao, Noriaki
Ando, Miki
Koike, Michiaki
author_sort Misawa, Kyohei
collection PubMed
description Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complement‐mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA and immune thrombocytopenia have been reported to develop following the mRNA COVID‐19 vaccination. However, PCH developing subsequent to mRNA vaccination has never been reported. We report a 59‐year‐old male who developed PCH approximately a month after his second mRNA COVID‐19 vaccination.
format Online
Article
Text
id pubmed-9349421
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93494212022-08-04 Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination Misawa, Kyohei Yasuda, Hajime Koyama, Daisuke Inano, Tadaaki Inoguchi, Akemi Shirasu, Chinami Takano, Hina Iwao, Noriaki Ando, Miki Koike, Michiaki EJHaem Case Reports Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complement‐mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA and immune thrombocytopenia have been reported to develop following the mRNA COVID‐19 vaccination. However, PCH developing subsequent to mRNA vaccination has never been reported. We report a 59‐year‐old male who developed PCH approximately a month after his second mRNA COVID‐19 vaccination. John Wiley and Sons Inc. 2022-06-15 /pmc/articles/PMC9349421/ /pubmed/35941885 http://dx.doi.org/10.1002/jha2.508 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Misawa, Kyohei
Yasuda, Hajime
Koyama, Daisuke
Inano, Tadaaki
Inoguchi, Akemi
Shirasu, Chinami
Takano, Hina
Iwao, Noriaki
Ando, Miki
Koike, Michiaki
Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
title Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
title_full Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
title_fullStr Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
title_full_unstemmed Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
title_short Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
title_sort adult paroxysmal cold hemoglobinuria following mrna covid‐19 vaccination
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349421/
https://www.ncbi.nlm.nih.gov/pubmed/35941885
http://dx.doi.org/10.1002/jha2.508
work_keys_str_mv AT misawakyohei adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT yasudahajime adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT koyamadaisuke adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT inanotadaaki adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT inoguchiakemi adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT shirasuchinami adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT takanohina adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT iwaonoriaki adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT andomiki adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination
AT koikemichiaki adultparoxysmalcoldhemoglobinuriafollowingmrnacovid19vaccination

Ejemplares similares