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Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases
BACKGROUND AND AIM: This study aims to investigate the effects of chronic coffee consumption (>5 years) and type of coffee in non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFLD) and patients who have regular alcohol consumption. MATERIALS AND METHODS: In this study, 158 health...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kare Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349493/ https://www.ncbi.nlm.nih.gov/pubmed/35949725 http://dx.doi.org/10.14744/hf.2020.2020.0026 |
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author | Degertekin, Bulent Tozun, Nurdan Soylemez, Aysegul Gizem Gurtay, Ezgi Bozkurt, Ugur Yilmaz, Yusuf Yapali, Suna Vardareli, Eser Unal, Hakan Umit Colakoglu, Berkan Alpaydin, Can Berk |
author_facet | Degertekin, Bulent Tozun, Nurdan Soylemez, Aysegul Gizem Gurtay, Ezgi Bozkurt, Ugur Yilmaz, Yusuf Yapali, Suna Vardareli, Eser Unal, Hakan Umit Colakoglu, Berkan Alpaydin, Can Berk |
author_sort | Degertekin, Bulent |
collection | PubMed |
description | BACKGROUND AND AIM: This study aims to investigate the effects of chronic coffee consumption (>5 years) and type of coffee in non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFLD) and patients who have regular alcohol consumption. MATERIALS AND METHODS: In this study, 158 healthy individuals and 101 patients with histologically proven NASH were enrolled. The daily amount of coffee intake, amount of alcohol use and type of coffee were calculated for all patients. The degree of steatosis and fibrosis was analyzed by transient elastography and liver ultrasound in non-NASH and by liver biopsy in NASH patients. RESULTS: Patients with a history of coffee consumption (n=132) had lower liver enzyme levels compared to the non-coffee group (n=127) (p=0.001). Serum ALT level was significantly lower [ALT: 21.2±11.7 U/L vs. 56.4±15.6 U/L (p=0.004)], and the liver histopathology was significantly better for patients with a coffee consumption of daily for >5years (p=0.045 for fibrosis score for NASH, p=0.036 for LSM and p=0.015 for CAP measurements for the non-NASH patient). CONCLUSION: Coffee seems to have a positive protective effect on liver histology and liver enzyme levels in healthy individuals, in patients with chronic alcohol consumption, NAFLD and NASH. These results are more prominent in patients who drink coffee on a regular daily base for more than five years. |
format | Online Article Text |
id | pubmed-9349493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Kare Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-93494932022-08-09 Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases Degertekin, Bulent Tozun, Nurdan Soylemez, Aysegul Gizem Gurtay, Ezgi Bozkurt, Ugur Yilmaz, Yusuf Yapali, Suna Vardareli, Eser Unal, Hakan Umit Colakoglu, Berkan Alpaydin, Can Berk Hepatol Forum Research Article BACKGROUND AND AIM: This study aims to investigate the effects of chronic coffee consumption (>5 years) and type of coffee in non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFLD) and patients who have regular alcohol consumption. MATERIALS AND METHODS: In this study, 158 healthy individuals and 101 patients with histologically proven NASH were enrolled. The daily amount of coffee intake, amount of alcohol use and type of coffee were calculated for all patients. The degree of steatosis and fibrosis was analyzed by transient elastography and liver ultrasound in non-NASH and by liver biopsy in NASH patients. RESULTS: Patients with a history of coffee consumption (n=132) had lower liver enzyme levels compared to the non-coffee group (n=127) (p=0.001). Serum ALT level was significantly lower [ALT: 21.2±11.7 U/L vs. 56.4±15.6 U/L (p=0.004)], and the liver histopathology was significantly better for patients with a coffee consumption of daily for >5years (p=0.045 for fibrosis score for NASH, p=0.036 for LSM and p=0.015 for CAP measurements for the non-NASH patient). CONCLUSION: Coffee seems to have a positive protective effect on liver histology and liver enzyme levels in healthy individuals, in patients with chronic alcohol consumption, NAFLD and NASH. These results are more prominent in patients who drink coffee on a regular daily base for more than five years. Kare Publishing 2020-09-21 /pmc/articles/PMC9349493/ /pubmed/35949725 http://dx.doi.org/10.14744/hf.2020.2020.0026 Text en © Copyright 2020 by Hepatology Forum https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Research Article Degertekin, Bulent Tozun, Nurdan Soylemez, Aysegul Gizem Gurtay, Ezgi Bozkurt, Ugur Yilmaz, Yusuf Yapali, Suna Vardareli, Eser Unal, Hakan Umit Colakoglu, Berkan Alpaydin, Can Berk Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases |
title | Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases |
title_full | Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases |
title_fullStr | Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases |
title_full_unstemmed | Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases |
title_short | Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases |
title_sort | regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: report of 259 cases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349493/ https://www.ncbi.nlm.nih.gov/pubmed/35949725 http://dx.doi.org/10.14744/hf.2020.2020.0026 |
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