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Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity
Patients infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 has increased worldwide since the beginning of 2022 and the variant has spread more rapidly than the Delta variant, which spread in the summer of 2021. It is important to clarify the cause of the strong tra...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349670/ https://www.ncbi.nlm.nih.gov/pubmed/35790476 http://dx.doi.org/10.1002/jmv.27974 |
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author | Yuasa, Sonoka Nakajima, Jun Takatsuki, Yuna Takahashi, Yuta Tani‐Sassa, Chihiro Iwasaki, Yumi Nagano, Katsutoshi Sonobe, Kazunari Yoshimoto, Tomoyo Nukui, Yoko Takeuchi, Hiroaki Tanimoto, Kousuke Tanaka, Yukie Kimura, Akinori Ichimura, Naoya Tohda, Shuji |
author_facet | Yuasa, Sonoka Nakajima, Jun Takatsuki, Yuna Takahashi, Yuta Tani‐Sassa, Chihiro Iwasaki, Yumi Nagano, Katsutoshi Sonobe, Kazunari Yoshimoto, Tomoyo Nukui, Yoko Takeuchi, Hiroaki Tanimoto, Kousuke Tanaka, Yukie Kimura, Akinori Ichimura, Naoya Tohda, Shuji |
author_sort | Yuasa, Sonoka |
collection | PubMed |
description | Patients infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 has increased worldwide since the beginning of 2022 and the variant has spread more rapidly than the Delta variant, which spread in the summer of 2021. It is important to clarify the cause of the strong transmissibility of the Omicron variant to control its spread. In 694 patients with coronavirus disease 2019, the copy numbers of virus in nasopharyngeal swab‐soaked samples and the viral genotypes were examined using quantitative polymerase chain reaction (PCR) and PCR‐based melting curve analysis, respectively. Whole‐genome sequencing was also performed to verify the viral genotyping data. There was no significant difference (p = 0.052) in the copy numbers between the Delta variant cases (median 1.5 × 10(5) copies/μl, n = 174) and Omicron variant cases (median 1.2 × 10(5) copies/μl, n = 328). During this study, Omicron BA.1 cases (median 1.1 ×10(5) copies/μl, n = 275) began to be replaced by BA.2 cases (median 2.3 × 10(5) copies/μl, n = 53), and there was no significant difference between the two groups (p = 0.33). Our results suggest that increased infectivity of the Omicron variant and its derivative BA.2 is not caused by higher viral loads but by other factors, such as increased affinity to cell receptors or immune escape. |
format | Online Article Text |
id | pubmed-9349670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93496702022-08-04 Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity Yuasa, Sonoka Nakajima, Jun Takatsuki, Yuna Takahashi, Yuta Tani‐Sassa, Chihiro Iwasaki, Yumi Nagano, Katsutoshi Sonobe, Kazunari Yoshimoto, Tomoyo Nukui, Yoko Takeuchi, Hiroaki Tanimoto, Kousuke Tanaka, Yukie Kimura, Akinori Ichimura, Naoya Tohda, Shuji J Med Virol Short Communications Patients infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 has increased worldwide since the beginning of 2022 and the variant has spread more rapidly than the Delta variant, which spread in the summer of 2021. It is important to clarify the cause of the strong transmissibility of the Omicron variant to control its spread. In 694 patients with coronavirus disease 2019, the copy numbers of virus in nasopharyngeal swab‐soaked samples and the viral genotypes were examined using quantitative polymerase chain reaction (PCR) and PCR‐based melting curve analysis, respectively. Whole‐genome sequencing was also performed to verify the viral genotyping data. There was no significant difference (p = 0.052) in the copy numbers between the Delta variant cases (median 1.5 × 10(5) copies/μl, n = 174) and Omicron variant cases (median 1.2 × 10(5) copies/μl, n = 328). During this study, Omicron BA.1 cases (median 1.1 ×10(5) copies/μl, n = 275) began to be replaced by BA.2 cases (median 2.3 × 10(5) copies/μl, n = 53), and there was no significant difference between the two groups (p = 0.33). Our results suggest that increased infectivity of the Omicron variant and its derivative BA.2 is not caused by higher viral loads but by other factors, such as increased affinity to cell receptors or immune escape. John Wiley and Sons Inc. 2022-07-11 2022-11 /pmc/articles/PMC9349670/ /pubmed/35790476 http://dx.doi.org/10.1002/jmv.27974 Text en © 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Short Communications Yuasa, Sonoka Nakajima, Jun Takatsuki, Yuna Takahashi, Yuta Tani‐Sassa, Chihiro Iwasaki, Yumi Nagano, Katsutoshi Sonobe, Kazunari Yoshimoto, Tomoyo Nukui, Yoko Takeuchi, Hiroaki Tanimoto, Kousuke Tanaka, Yukie Kimura, Akinori Ichimura, Naoya Tohda, Shuji Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity |
title | Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity |
title_full | Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity |
title_fullStr | Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity |
title_full_unstemmed | Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity |
title_short | Viral load of SARS‐CoV‐2 Omicron is not high despite its high infectivity |
title_sort | viral load of sars‐cov‐2 omicron is not high despite its high infectivity |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349670/ https://www.ncbi.nlm.nih.gov/pubmed/35790476 http://dx.doi.org/10.1002/jmv.27974 |
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