Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs

The emergence of more transmissible or aggressive variants of SARS‐CoV‐2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized small interfering RNA (siRNA) against SARS‐CoV‐2. The siRNA c...

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Detalles Bibliográficos
Autores principales: Traube, Franziska R., Stern, Marcel, Tölke, Annika J., Rudelius, Martina, Mejías‐Pérez, Ernesto, Raddaoui, Nada, Kümmerer, Beate M., Douat, Céline, Streshnev, Filipp, Albanese, Manuel, Wratil, Paul R., Gärtner, Yasmin V., Nainytė, Milda, Giorgio, Grazia, Michalakis, Stylianos, Schneider, Sabine, Streeck, Hendrik, Müller, Markus, Keppler, Oliver T., Carell, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350007/
https://www.ncbi.nlm.nih.gov/pubmed/35802496
http://dx.doi.org/10.1002/anie.202204556

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