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Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs
The emergence of more transmissible or aggressive variants of SARS‐CoV‐2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized small interfering RNA (siRNA) against SARS‐CoV‐2. The siRNA c...
Autores principales: | Traube, Franziska R., Stern, Marcel, Tölke, Annika J., Rudelius, Martina, Mejías‐Pérez, Ernesto, Raddaoui, Nada, Kümmerer, Beate M., Douat, Céline, Streshnev, Filipp, Albanese, Manuel, Wratil, Paul R., Gärtner, Yasmin V., Nainytė, Milda, Giorgio, Grazia, Michalakis, Stylianos, Schneider, Sabine, Streeck, Hendrik, Müller, Markus, Keppler, Oliver T., Carell, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350007/ https://www.ncbi.nlm.nih.gov/pubmed/35802496 http://dx.doi.org/10.1002/anie.202204556 |
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