COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions

We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hypo...

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Detalles Bibliográficos
Autores principales: Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350042/
https://www.ncbi.nlm.nih.gov/pubmed/35689332
http://dx.doi.org/10.1002/eji.202249827
Descripción
Sumario:We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID‐19 patients. [Image: see text]

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