COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions

We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hypo...

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Autores principales: Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Notes and Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350042/
https://www.ncbi.nlm.nih.gov/pubmed/35689332
http://dx.doi.org/10.1002/eji.202249827
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author Schrijver, Irene T.
Théroude, Charlotte
Antonakos, Nikolaos
Regina, Jean
Le Roy, Didier
Bart, Pierre‐Alexandre
Chiche, Jean‐Daniel
Perreau, Matthieu
Pantaleo, Giuseppe
Calandra, Thierry
Roger, Thierry
author_facet Schrijver, Irene T.
Théroude, Charlotte
Antonakos, Nikolaos
Regina, Jean
Le Roy, Didier
Bart, Pierre‐Alexandre
Chiche, Jean‐Daniel
Perreau, Matthieu
Pantaleo, Giuseppe
Calandra, Thierry
Roger, Thierry
author_sort Schrijver, Irene T.
collection PubMed
description We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID‐19 patients. [Image: see text]
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spelling pubmed-93500422022-08-04 COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions Schrijver, Irene T. Théroude, Charlotte Antonakos, Nikolaos Regina, Jean Le Roy, Didier Bart, Pierre‐Alexandre Chiche, Jean‐Daniel Perreau, Matthieu Pantaleo, Giuseppe Calandra, Thierry Roger, Thierry Eur J Immunol Notes and Insights We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID‐19 patients. [Image: see text] John Wiley and Sons Inc. 2022-06-24 2022-10 /pmc/articles/PMC9350042/ /pubmed/35689332 http://dx.doi.org/10.1002/eji.202249827 Text en © 2022 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Notes and Insights
Schrijver, Irene T.
Théroude, Charlotte
Antonakos, Nikolaos
Regina, Jean
Le Roy, Didier
Bart, Pierre‐Alexandre
Chiche, Jean‐Daniel
Perreau, Matthieu
Pantaleo, Giuseppe
Calandra, Thierry
Roger, Thierry
COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
title COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
title_full COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
title_fullStr COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
title_full_unstemmed COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
title_short COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
title_sort covid‐19 rapidly increases mdscs and prolongs innate immune dysfunctions
topic Notes and Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350042/
https://www.ncbi.nlm.nih.gov/pubmed/35689332
http://dx.doi.org/10.1002/eji.202249827
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