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Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

OBJECTIVES: The prognostic significance of SYNTAX Score II (SS-II) is well-known in patients with chronic coronary syndromes. However, its predictive ability for mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI) rem...

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Autores principales: Kocas, Betul Balaban, Cetinkal, Gokhan, Kocas, Cuneyt, Arslan, Sukru, Abaci, Okay, Dalgic, Yalcin, Ser, Ozgur Selim, Batit, Servet, Yildiz, Ahmet, Dogan, Sait Mesut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Med Bull Sisli Etfal Hosp 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350066/
https://www.ncbi.nlm.nih.gov/pubmed/35990300
http://dx.doi.org/10.14744/SEMB.2021.33410
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author Kocas, Betul Balaban
Cetinkal, Gokhan
Kocas, Cuneyt
Arslan, Sukru
Abaci, Okay
Dalgic, Yalcin
Ser, Ozgur Selim
Batit, Servet
Yildiz, Ahmet
Dogan, Sait Mesut
author_facet Kocas, Betul Balaban
Cetinkal, Gokhan
Kocas, Cuneyt
Arslan, Sukru
Abaci, Okay
Dalgic, Yalcin
Ser, Ozgur Selim
Batit, Servet
Yildiz, Ahmet
Dogan, Sait Mesut
author_sort Kocas, Betul Balaban
collection PubMed
description OBJECTIVES: The prognostic significance of SYNTAX Score II (SS-II) is well-known in patients with chronic coronary syndromes. However, its predictive ability for mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI) remains unclear. Therefore, we aimed to investigate the prognostic accuracy of SS-II in STEMI patients who underwent p-PCI. METHODS: A total of 743 STEMI patients treated with p-PCI were retrospectively analyzed. Study population was divided into three groups according to SS-II and defined as SS-IILOW ≤22.5 (n=245), 22.5 <SS-II MID ≤31 (n=243) and SS-II HIGH >31 (n=255). In-hospital and long-term mortality at long-term follow-up were defined as clinical endpoints of the study. RESULTS: The incidence of in-hospital (15% vs. 0.4% vs. 0.8%, p<0.001) and all-cause mortality (32.2% vs. 6.6% vs. 2.9%, p<0.001) were significantly higher in SS-IIHIGH group compared with the other two groups. In addition, Kaplan–Meier analysis showed statistically significantly increased incidence of death in SS-II > 31 group (P [log-rank] <0.001). SS-II >31 was defined as an independent predictor of all-cause mortality (hazard ratio 5.22 95% confidence interval 2.11–12.87 p<0.001). Area under the curve values derived from ROC analysis to evaluate the predictive accuracy of SS-II, anatomical and clinical SS, modified ACEF score, and Global Registry of Acute Coronary Events risk scores for all-cause mortality were 0.82, 0.71, 0.81, 0.82, and 0.82, respectively (p<0.001). CONCLUSION: SS-II has an increased predictive ability for in-hospital and long-term mortality in STEMI patients undergoing p-PCI.
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spelling pubmed-93500662022-08-18 Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention Kocas, Betul Balaban Cetinkal, Gokhan Kocas, Cuneyt Arslan, Sukru Abaci, Okay Dalgic, Yalcin Ser, Ozgur Selim Batit, Servet Yildiz, Ahmet Dogan, Sait Mesut Sisli Etfal Hastan Tip Bul Original Research OBJECTIVES: The prognostic significance of SYNTAX Score II (SS-II) is well-known in patients with chronic coronary syndromes. However, its predictive ability for mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI) remains unclear. Therefore, we aimed to investigate the prognostic accuracy of SS-II in STEMI patients who underwent p-PCI. METHODS: A total of 743 STEMI patients treated with p-PCI were retrospectively analyzed. Study population was divided into three groups according to SS-II and defined as SS-IILOW ≤22.5 (n=245), 22.5 <SS-II MID ≤31 (n=243) and SS-II HIGH >31 (n=255). In-hospital and long-term mortality at long-term follow-up were defined as clinical endpoints of the study. RESULTS: The incidence of in-hospital (15% vs. 0.4% vs. 0.8%, p<0.001) and all-cause mortality (32.2% vs. 6.6% vs. 2.9%, p<0.001) were significantly higher in SS-IIHIGH group compared with the other two groups. In addition, Kaplan–Meier analysis showed statistically significantly increased incidence of death in SS-II > 31 group (P [log-rank] <0.001). SS-II >31 was defined as an independent predictor of all-cause mortality (hazard ratio 5.22 95% confidence interval 2.11–12.87 p<0.001). Area under the curve values derived from ROC analysis to evaluate the predictive accuracy of SS-II, anatomical and clinical SS, modified ACEF score, and Global Registry of Acute Coronary Events risk scores for all-cause mortality were 0.82, 0.71, 0.81, 0.82, and 0.82, respectively (p<0.001). CONCLUSION: SS-II has an increased predictive ability for in-hospital and long-term mortality in STEMI patients undergoing p-PCI. Med Bull Sisli Etfal Hosp 2022-06-28 /pmc/articles/PMC9350066/ /pubmed/35990300 http://dx.doi.org/10.14744/SEMB.2021.33410 Text en © Copyright 2022 by The Medical Bulletin of Sisli Etfal Hospital https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Research
Kocas, Betul Balaban
Cetinkal, Gokhan
Kocas, Cuneyt
Arslan, Sukru
Abaci, Okay
Dalgic, Yalcin
Ser, Ozgur Selim
Batit, Servet
Yildiz, Ahmet
Dogan, Sait Mesut
Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
title Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
title_full Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
title_fullStr Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
title_full_unstemmed Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
title_short Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
title_sort usefulness of the syntax score ii to predict in-hospital and long-term mortality in st-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350066/
https://www.ncbi.nlm.nih.gov/pubmed/35990300
http://dx.doi.org/10.14744/SEMB.2021.33410
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