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Chasing up and locking down the virus: Optimal pandemic interventions within a network

During the COVID‐19 pandemic countries invested significant amounts of resources into its containment. In early stages of the pandemic most of the (nonpharmaceutical) interventions can be classified into two groups: (i) testing and identification of infected individuals, (ii) social distancing measu...

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Autores principales: Freiberger, Michael, Grass, Dieter, Kuhn, Michael, Seidl, Andrea, Wrzaczek, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350112/
https://www.ncbi.nlm.nih.gov/pubmed/35942308
http://dx.doi.org/10.1111/jpet.12604
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author Freiberger, Michael
Grass, Dieter
Kuhn, Michael
Seidl, Andrea
Wrzaczek, Stefan
author_facet Freiberger, Michael
Grass, Dieter
Kuhn, Michael
Seidl, Andrea
Wrzaczek, Stefan
author_sort Freiberger, Michael
collection PubMed
description During the COVID‐19 pandemic countries invested significant amounts of resources into its containment. In early stages of the pandemic most of the (nonpharmaceutical) interventions can be classified into two groups: (i) testing and identification of infected individuals, (ii) social distancing measures to reduce the transmission probabilities. Furthermore, both groups of measures may, in principle, be targeted at certain subgroups of a networked population. To study such a problem, we propose an extension of the SIR model with additional compartments for quarantine and different courses of the disease across several network nodes. We develop the structure of the optimal allocation and study a numerical example of three symmetric regions that are subject to an asymmetric progression of the disease (starting from an initial hotspot). Key findings include that (i) for our calibrations policies are chosen in a “flattening‐the‐curve,” avoiding hospital congestion; (ii) policies shift from containing spillovers from the hotspot initially to establishing a symmetric pattern of the disease; and (iii) testing that can be effectively targeted allows to reduce substantially the duration of the disease, hospital congestion and the total cost, both in terms of lives lost and economic costs.
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spelling pubmed-93501122022-08-04 Chasing up and locking down the virus: Optimal pandemic interventions within a network Freiberger, Michael Grass, Dieter Kuhn, Michael Seidl, Andrea Wrzaczek, Stefan J Public Econ Theory Original Articles During the COVID‐19 pandemic countries invested significant amounts of resources into its containment. In early stages of the pandemic most of the (nonpharmaceutical) interventions can be classified into two groups: (i) testing and identification of infected individuals, (ii) social distancing measures to reduce the transmission probabilities. Furthermore, both groups of measures may, in principle, be targeted at certain subgroups of a networked population. To study such a problem, we propose an extension of the SIR model with additional compartments for quarantine and different courses of the disease across several network nodes. We develop the structure of the optimal allocation and study a numerical example of three symmetric regions that are subject to an asymmetric progression of the disease (starting from an initial hotspot). Key findings include that (i) for our calibrations policies are chosen in a “flattening‐the‐curve,” avoiding hospital congestion; (ii) policies shift from containing spillovers from the hotspot initially to establishing a symmetric pattern of the disease; and (iii) testing that can be effectively targeted allows to reduce substantially the duration of the disease, hospital congestion and the total cost, both in terms of lives lost and economic costs. John Wiley and Sons Inc. 2022-06-29 /pmc/articles/PMC9350112/ /pubmed/35942308 http://dx.doi.org/10.1111/jpet.12604 Text en © 2022 Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Freiberger, Michael
Grass, Dieter
Kuhn, Michael
Seidl, Andrea
Wrzaczek, Stefan
Chasing up and locking down the virus: Optimal pandemic interventions within a network
title Chasing up and locking down the virus: Optimal pandemic interventions within a network
title_full Chasing up and locking down the virus: Optimal pandemic interventions within a network
title_fullStr Chasing up and locking down the virus: Optimal pandemic interventions within a network
title_full_unstemmed Chasing up and locking down the virus: Optimal pandemic interventions within a network
title_short Chasing up and locking down the virus: Optimal pandemic interventions within a network
title_sort chasing up and locking down the virus: optimal pandemic interventions within a network
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350112/
https://www.ncbi.nlm.nih.gov/pubmed/35942308
http://dx.doi.org/10.1111/jpet.12604
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