Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases

The SARS‐CoV‐2 infection cycle is a multistage process that relies on functional interactions between the host and the pathogen. Here, we repurposed antiviral drugs against both viral and host enzymes to pharmaceutically block methylation of the viral RNA 2'‐O‐ribose cap needed for viral immune...

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Detalles Bibliográficos
Autores principales: Bergant, Valter, Yamada, Shintaro, Grass, Vincent, Tsukamoto, Yuta, Lavacca, Teresa, Krey, Karsten, Mühlhofer, Maria‐Teresa, Wittmann, Sabine, Ensser, Armin, Herrmann, Alexandra, vom Hemdt, Anja, Tomita, Yuriko, Matsuyama, Shutoku, Hirokawa, Takatsugu, Huang, Yiqi, Piras, Antonio, Jakwerth, Constanze A, Oelsner, Madlen, Thieme, Susanne, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Kümmerer, Beate M, Stukalov, Alexey, Schmidt‐Weber, Carsten B, Igarashi, Manabu, Gramberg, Thomas, Pichlmair, Andreas, Kato, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350232/
https://www.ncbi.nlm.nih.gov/pubmed/35833542
http://dx.doi.org/10.15252/embj.2022111608

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