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Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries
Acute cardiac injuries occur in 20%–25% of hospitalized COVID‐19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID‐19 hyperinflammation. As IL‐1β is an upstream cytokine and a core COVID‐19 signature cytokine, it...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350263/ https://www.ncbi.nlm.nih.gov/pubmed/35689600 http://dx.doi.org/10.1002/term.3327 |
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author | Arhontoulis, Dimitrios C. Kerr, Charles M. Richards, Dylan Tjen, Kelsey Hyams, Nathaniel Jones, Jefferey A. Deleon‐Pennell, Kristine Menick, Donald Bräuninger, Hanna Lindner, Diana Westermann, Dirk Mei, Ying |
author_facet | Arhontoulis, Dimitrios C. Kerr, Charles M. Richards, Dylan Tjen, Kelsey Hyams, Nathaniel Jones, Jefferey A. Deleon‐Pennell, Kristine Menick, Donald Bräuninger, Hanna Lindner, Diana Westermann, Dirk Mei, Ying |
author_sort | Arhontoulis, Dimitrios C. |
collection | PubMed |
description | Acute cardiac injuries occur in 20%–25% of hospitalized COVID‐19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID‐19 hyperinflammation. As IL‐1β is an upstream cytokine and a core COVID‐19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID‐19 cytokine storm. The IL‐1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID‐19 hearts. The comparison of IL‐1β treated hCOs with cardiac tissue from COVID‐19 autopsies illustrated the critical roles of hyper‐inflammation in COVID‐19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL‐1β treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID‐19 cardiac injuries at baseline and simulated exercise conditions. |
format | Online Article Text |
id | pubmed-9350263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93502632022-08-04 Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries Arhontoulis, Dimitrios C. Kerr, Charles M. Richards, Dylan Tjen, Kelsey Hyams, Nathaniel Jones, Jefferey A. Deleon‐Pennell, Kristine Menick, Donald Bräuninger, Hanna Lindner, Diana Westermann, Dirk Mei, Ying J Tissue Eng Regen Med Research Articles Acute cardiac injuries occur in 20%–25% of hospitalized COVID‐19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID‐19 hyperinflammation. As IL‐1β is an upstream cytokine and a core COVID‐19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID‐19 cytokine storm. The IL‐1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID‐19 hearts. The comparison of IL‐1β treated hCOs with cardiac tissue from COVID‐19 autopsies illustrated the critical roles of hyper‐inflammation in COVID‐19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL‐1β treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID‐19 cardiac injuries at baseline and simulated exercise conditions. John Wiley and Sons Inc. 2022-06-11 2022-09 /pmc/articles/PMC9350263/ /pubmed/35689600 http://dx.doi.org/10.1002/term.3327 Text en © 2022 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Arhontoulis, Dimitrios C. Kerr, Charles M. Richards, Dylan Tjen, Kelsey Hyams, Nathaniel Jones, Jefferey A. Deleon‐Pennell, Kristine Menick, Donald Bräuninger, Hanna Lindner, Diana Westermann, Dirk Mei, Ying Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries |
title | Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries |
title_full | Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries |
title_fullStr | Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries |
title_full_unstemmed | Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries |
title_short | Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries |
title_sort | human cardiac organoids to model covid‐19 cytokine storm induced cardiac injuries |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350263/ https://www.ncbi.nlm.nih.gov/pubmed/35689600 http://dx.doi.org/10.1002/term.3327 |
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