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GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation

Left ventricular diastolic dysfunction is a structural and functional condition that precedes the development of heart failure with preserved ejection fraction (HFpEF). The etiology of diastolic dysfunction includes alterations in fuel substrate metabolism that negatively impact cardiac bioenergetic...

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Detalles Bibliográficos
Autores principales:	Thapa, Dharendra, Bugga, Paramesha, Mushala, Bellina A. S., Manning, Janet R., Stoner, Michael W., McMahon, Brenda, Zeng, Xuemei, Cantrell, Pamela S., Yates, Nathan, Xie, Bingxian, Edmunds, Lia R., Jurczak, Michael J., Scott, Iain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350469/ https://www.ncbi.nlm.nih.gov/pubmed/35924321 http://dx.doi.org/10.14814/phy2.15415

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