Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses

Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal centers (GCs), but the mechanisms governing the recruitment to GCs on secondary challenges remain unclear. Here, using preclinical SARS-CoV and HIV mouse models, we demonstrated that the antibodies elicited...

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Detalles Bibliográficos
Autores principales: Tas, Jeroen M.J., Koo, Ja-Hyun, Lin, Ying-Cing, Xie, Zhenfei, Steichen, Jon M., Jackson, Abigail M., Hauser, Blake M., Wang, Xuesong, Cottrell, Christopher A., Torres, Jonathan L., Warner, John E., Kirsch, Kathrin H., Weldon, Stephanie R., Groschel, Bettina, Nogal, Bartek, Ozorowski, Gabriel, Bangaru, Sandhya, Phelps, Nicole, Adachi, Yumiko, Eskandarzadeh, Saman, Kubitz, Michael, Burton, Dennis R., Lingwood, Daniel, Schmidt, Aaron G., Nair, Usha, Ward, Andrew B., Schief, William R., Batista, Facundo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350677/
https://www.ncbi.nlm.nih.gov/pubmed/35987201
http://dx.doi.org/10.1016/j.immuni.2022.07.020

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