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Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research

Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global concern for many health and regulatory agencies due to their widespread use and persistence in the environment (in soil, air, and water), bioaccumulation, and toxicity. This concern has catalyzed a need to aggrega...

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Autores principales: Williams, Antony J., Gaines, Linda G. T., Grulke, Christopher M., Lowe, Charles N., Sinclair, Gabriel F. B., Samano, Vicente, Thillainadarajah, Inthirany, Meyer, Bryan, Patlewicz, Grace, Richard, Ann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350880/
https://www.ncbi.nlm.nih.gov/pubmed/35936994
http://dx.doi.org/10.3389/fenvs.2022.850019
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author Williams, Antony J.
Gaines, Linda G. T.
Grulke, Christopher M.
Lowe, Charles N.
Sinclair, Gabriel F. B.
Samano, Vicente
Thillainadarajah, Inthirany
Meyer, Bryan
Patlewicz, Grace
Richard, Ann M.
author_facet Williams, Antony J.
Gaines, Linda G. T.
Grulke, Christopher M.
Lowe, Charles N.
Sinclair, Gabriel F. B.
Samano, Vicente
Thillainadarajah, Inthirany
Meyer, Bryan
Patlewicz, Grace
Richard, Ann M.
author_sort Williams, Antony J.
collection PubMed
description Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global concern for many health and regulatory agencies due to their widespread use and persistence in the environment (in soil, air, and water), bioaccumulation, and toxicity. This concern has catalyzed a need to aggregate data to support research efforts that can, in turn, inform regulatory and statutory actions. An ongoing challenge regarding PFAS has been the shifting definition of what qualifies a substance to be a member of the PFAS class. There is no single definition for a PFAS, but various attempts have been made to utilize substructural definitions that either encompass broad working scopes or satisfy narrower regulatory guidelines. Depending on the size and specificity of PFAS substructural filters applied to the U.S. Environmental Protection Agency (EPA) DSSTox database, currently exceeding 900,000 unique substances, PFAS substructure-defined space can span hundreds to tens of thousands of compounds. This manuscript reports on the curation of PFAS chemicals and assembly of lists that have been made publicly available to the community via the EPA’s CompTox Chemicals Dashboard. Creation of these PFAS lists required the harvesting of data from EPA and online databases, peer-reviewed publications, and regulatory documents. These data have been extracted and manually curated, annotated with structures, and made available to the community in the form of lists defined by structure filters, as well as lists comprising non-structurable PFAS, such as polymers and complex mixtures. These lists, along with their associated linkages to predicted and measured data, are fueling PFAS research efforts within the EPA and are serving as a valuable resource to the international scientific community.
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spelling pubmed-93508802023-04-05 Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research Williams, Antony J. Gaines, Linda G. T. Grulke, Christopher M. Lowe, Charles N. Sinclair, Gabriel F. B. Samano, Vicente Thillainadarajah, Inthirany Meyer, Bryan Patlewicz, Grace Richard, Ann M. Front Environ Sci Article Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global concern for many health and regulatory agencies due to their widespread use and persistence in the environment (in soil, air, and water), bioaccumulation, and toxicity. This concern has catalyzed a need to aggregate data to support research efforts that can, in turn, inform regulatory and statutory actions. An ongoing challenge regarding PFAS has been the shifting definition of what qualifies a substance to be a member of the PFAS class. There is no single definition for a PFAS, but various attempts have been made to utilize substructural definitions that either encompass broad working scopes or satisfy narrower regulatory guidelines. Depending on the size and specificity of PFAS substructural filters applied to the U.S. Environmental Protection Agency (EPA) DSSTox database, currently exceeding 900,000 unique substances, PFAS substructure-defined space can span hundreds to tens of thousands of compounds. This manuscript reports on the curation of PFAS chemicals and assembly of lists that have been made publicly available to the community via the EPA’s CompTox Chemicals Dashboard. Creation of these PFAS lists required the harvesting of data from EPA and online databases, peer-reviewed publications, and regulatory documents. These data have been extracted and manually curated, annotated with structures, and made available to the community in the form of lists defined by structure filters, as well as lists comprising non-structurable PFAS, such as polymers and complex mixtures. These lists, along with their associated linkages to predicted and measured data, are fueling PFAS research efforts within the EPA and are serving as a valuable resource to the international scientific community. 2022-04-05 /pmc/articles/PMC9350880/ /pubmed/35936994 http://dx.doi.org/10.3389/fenvs.2022.850019 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Article
Williams, Antony J.
Gaines, Linda G. T.
Grulke, Christopher M.
Lowe, Charles N.
Sinclair, Gabriel F. B.
Samano, Vicente
Thillainadarajah, Inthirany
Meyer, Bryan
Patlewicz, Grace
Richard, Ann M.
Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research
title Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research
title_full Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research
title_fullStr Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research
title_full_unstemmed Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research
title_short Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research
title_sort assembly and curation of lists of per- and polyfluoroalkyl substances (pfas) to support environmental science research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350880/
https://www.ncbi.nlm.nih.gov/pubmed/35936994
http://dx.doi.org/10.3389/fenvs.2022.850019
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