Probing the cell delivery of synthetic diubiquitin chains

In this study, the live-cell delivery of structurally different synthetic diubiquitin chains was examined. We found that the combination of structural variations of the Ub chains (intrinsic factors); nature of CPP and CPP-protein linkage (extrinsic factors) influence their delivery.

Detalles Bibliográficos
Autores principales: Mandal, Shaswati, Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350984/
https://www.ncbi.nlm.nih.gov/pubmed/35837864
http://dx.doi.org/10.1039/d2cc02476d
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author Mandal, Shaswati
Brik, Ashraf
author_facet Mandal, Shaswati
Brik, Ashraf
author_sort Mandal, Shaswati
collection PubMed
description In this study, the live-cell delivery of structurally different synthetic diubiquitin chains was examined. We found that the combination of structural variations of the Ub chains (intrinsic factors); nature of CPP and CPP-protein linkage (extrinsic factors) influence their delivery.
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spelling pubmed-93509842022-08-29 Probing the cell delivery of synthetic diubiquitin chains Mandal, Shaswati Brik, Ashraf Chem Commun (Camb) Chemistry In this study, the live-cell delivery of structurally different synthetic diubiquitin chains was examined. We found that the combination of structural variations of the Ub chains (intrinsic factors); nature of CPP and CPP-protein linkage (extrinsic factors) influence their delivery. The Royal Society of Chemistry 2022-07-15 /pmc/articles/PMC9350984/ /pubmed/35837864 http://dx.doi.org/10.1039/d2cc02476d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Mandal, Shaswati
Brik, Ashraf
Probing the cell delivery of synthetic diubiquitin chains
title Probing the cell delivery of synthetic diubiquitin chains
title_full Probing the cell delivery of synthetic diubiquitin chains
title_fullStr Probing the cell delivery of synthetic diubiquitin chains
title_full_unstemmed Probing the cell delivery of synthetic diubiquitin chains
title_short Probing the cell delivery of synthetic diubiquitin chains
title_sort probing the cell delivery of synthetic diubiquitin chains
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350984/
https://www.ncbi.nlm.nih.gov/pubmed/35837864
http://dx.doi.org/10.1039/d2cc02476d
work_keys_str_mv AT mandalshaswati probingthecelldeliveryofsyntheticdiubiquitinchains
AT brikashraf probingthecelldeliveryofsyntheticdiubiquitinchains

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