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MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

BACKGROUND: The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene, which catalyzes the rate-limiting step in DNA replication. The major failure of 5FU-based cancer therapy is the developme...

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Detalles Bibliográficos
Autor principal:	Matuszyk, Janusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351108/ https://www.ncbi.nlm.nih.gov/pubmed/35922756 http://dx.doi.org/10.1186/s10020-022-00516-2

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