Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

BACKGROUND: Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases. Herein, we have investigated the role of NK1R receptor inhibition using Aprepitant to...

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Detalles Bibliográficos
Autores principales: Jin, Peng, Qi, Dongqing, Cui, Yuhui, Lenahan, Cameron, Zhang, John H., Tao, Xiaogen, Deng, Shuixiang, Tang, Jiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351153/
https://www.ncbi.nlm.nih.gov/pubmed/35922848
http://dx.doi.org/10.1186/s12974-022-02558-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351153/
https://www.ncbi.nlm.nih.gov/pubmed/35922848
http://dx.doi.org/10.1186/s12974-022-02558-z

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