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Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development
Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-specific birth defects called ribosomopathies, which frequently a...
Autores principales: | Falcon, Karla T., Watt, Kristin E. N., Dash, Soma, Zhao, Ruonan, Sakai, Daisuke, Moore, Emma L., Fitriasari, Sharien, Childers, Melissa, Sardiu, Mihaela E., Swanson, Selene, Tsuchiya, Dai, Unruh, Jay, Bugarinovic, George, Li, Lin, Shiang, Rita, Achilleos, Annita, Dixon, Jill, Dixon, Michael J., Trainor, Paul A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351356/ https://www.ncbi.nlm.nih.gov/pubmed/35881792 http://dx.doi.org/10.1073/pnas.2116974119 |
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