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Secretion of functional α1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy
Heterologous expression of proteins is used widely for the biosynthesis of biologics, many of which are secreted from cells. In addition, gene therapy and messenger RNA (mRNA) vaccines frequently direct the expression of secretory proteins to nonnative host cells. Consequently, it is crucial to unde...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351467/ https://www.ncbi.nlm.nih.gov/pubmed/35901208 http://dx.doi.org/10.1073/pnas.2206103119 |