A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy

Somatic mutations are accumulated in normal human tissues with aging and exposure to carcinogens. If we can accurately count any passenger mutations in any single DNA molecule, since their quantity is much larger than driver mutations, we can sensitively detect mutation accumulation in polyclonal no...

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Detalles Bibliográficos
Autores principales: Ueda, Sho, Yamashita, Satoshi, Nakajima, Miho, Kumamoto, Tadashi, Ogawa, Chitose, Liu, Yu-yu, Yamada, Harumi, Kubo, Emi, Hattori, Naoko, Takeshima, Hideyuki, Wakabayashi, Mika, Iida, Naoko, Shiraishi, Yuichi, Noguchi, Masayuki, Sato, Yukio, Ushijima, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351471/
https://www.ncbi.nlm.nih.gov/pubmed/35895679
http://dx.doi.org/10.1073/pnas.2123241119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351471/
https://www.ncbi.nlm.nih.gov/pubmed/35895679
http://dx.doi.org/10.1073/pnas.2123241119

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