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Shelterin is a dimeric complex with extensive structural heterogeneity

Human shelterin is a six-subunit complex—composed of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA. Although high-resolution structures have been generated of the individual structured domains w...

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Detalles Bibliográficos
Autores principales:	Zinder, John C., Olinares, Paul Dominic B., Svetlov, Vladimir, Bush, Martin W., Nudler, Evgeny, Chait, Brian T., Walz, Thomas, de Lange, Titia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351484/ https://www.ncbi.nlm.nih.gov/pubmed/35881804 http://dx.doi.org/10.1073/pnas.2201662119

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