Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements

The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in dosing across transplant types. We hypothesized...

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Detalles Bibliográficos
Autores principales: Khan, Mohammad Haneef, Onyeaghala, Guillaume C., Rashidi, Armin, Holtan, Shernan G., Khoruts, Alexander, Israni, Ajay, Jacobson, Pamala A., Staley, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351555/
https://www.ncbi.nlm.nih.gov/pubmed/35921529
http://dx.doi.org/10.1080/19490976.2022.2108279

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