PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes

PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown. Here, we report a central function of PARP12 in thermogenic adipocytes. We show that PARP12 is highly expressed in brow...

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Detalles Bibliográficos
Autores principales: Hu, Fan, Li, Chang, Ye, Yafen, Lu, Xuhong, Alimujiang, Miriayi, Bai, Ningning, Sun, Jingjing, Ma, Xiaojing, Li, Xiaohua, Yang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351573/
https://www.ncbi.nlm.nih.gov/pubmed/35916471
http://dx.doi.org/10.1080/21623945.2022.2091206
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author Hu, Fan
Li, Chang
Ye, Yafen
Lu, Xuhong
Alimujiang, Miriayi
Bai, Ningning
Sun, Jingjing
Ma, Xiaojing
Li, Xiaohua
Yang, Ying
author_facet Hu, Fan
Li, Chang
Ye, Yafen
Lu, Xuhong
Alimujiang, Miriayi
Bai, Ningning
Sun, Jingjing
Ma, Xiaojing
Li, Xiaohua
Yang, Ying
author_sort Hu, Fan
collection PubMed
description PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown. Here, we report a central function of PARP12 in thermogenic adipocytes. We show that PARP12 is highly expressed in brown adipose tissue and is mainly localized to the mitochondria. Knockdown of PARP12 in vitro reduced UCP1 expression. In parallel, the deficiency of PARP12 reduced mitochondrial respiration in adipocytes, while overexpression of PARP12 reversed these effects.
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spelling pubmed-93515732022-08-05 PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes Hu, Fan Li, Chang Ye, Yafen Lu, Xuhong Alimujiang, Miriayi Bai, Ningning Sun, Jingjing Ma, Xiaojing Li, Xiaohua Yang, Ying Adipocyte Research Paper PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown. Here, we report a central function of PARP12 in thermogenic adipocytes. We show that PARP12 is highly expressed in brown adipose tissue and is mainly localized to the mitochondria. Knockdown of PARP12 in vitro reduced UCP1 expression. In parallel, the deficiency of PARP12 reduced mitochondrial respiration in adipocytes, while overexpression of PARP12 reversed these effects. Taylor & Francis 2022-08-02 /pmc/articles/PMC9351573/ /pubmed/35916471 http://dx.doi.org/10.1080/21623945.2022.2091206 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Hu, Fan
Li, Chang
Ye, Yafen
Lu, Xuhong
Alimujiang, Miriayi
Bai, Ningning
Sun, Jingjing
Ma, Xiaojing
Li, Xiaohua
Yang, Ying
PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
title PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
title_full PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
title_fullStr PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
title_full_unstemmed PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
title_short PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
title_sort parp12 is required for mitochondrial function maintenance in thermogenic adipocytes
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351573/
https://www.ncbi.nlm.nih.gov/pubmed/35916471
http://dx.doi.org/10.1080/21623945.2022.2091206
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