Cargando…

In Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinoma

Cholangiocarcinoma (CCA) is a heterogenous group of malignancies in the bile duct, which proliferates aggressively. CCA is highly prevalent in Northeastern Thailand wherein it is associated with liver fluke infection, or Opisthorchis viverrini (OV). Most patients are diagnosed in advanced stages, wh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balasubramanian, Brinda, Venkatraman, Simran, Myint, Kyaw Zwar, Krobthong, Sucheewin, Wongtrakoongate, Patompon, Sripa, Jittiyawadee, Rattanasinganchan, Panthip, Metheenukul, Pornphimon, Tohtong, Rutaiwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351686/ https://www.ncbi.nlm.nih.gov/pubmed/35889537 http://dx.doi.org/10.3390/molecules27144664

Ejemplares similares

RTK25: A Comprehensive Molecular Profiling Strategy in Cholangiocarcinoma Using an Integrated Bioinformatics Approach
por: Balasubramanian, Brinda, et al.
Publicado: (2021)

Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway
por: Myint, Kyaw Zwar, et al.
Publicado: (2018)

Porcine placenta extract improves high-glucose-induced angiogenesis impairment
por: Nensat, Chatchai, et al.
Publicado: (2021)

Co-Clinical Trials: An Innovative Drug Development Platform for Cholangiocarcinoma
por: Balasubramanian, Brinda, et al.
Publicado: (2021)

Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma
por: Balasubramanian, Brinda, et al.
Publicado: (2023)

Molecularly Guided Drug Repurposing for Cholangiocarcinoma: An Integrative Bioinformatic Approach
por: Venkatraman, Simran, et al.
Publicado: (2022)

Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells
por: Boonsri, Boonyakorn, et al.
Publicado: (2021)

Differential plasma proteomes of the patients with Opisthorchiasis viverrini and cholangiocarcinoma identify a polymeric immunoglobulin receptor as a potential biomarker
por: Prasopdee, Sattrachai, et al.
Publicado: (2022)

Proteomics and Molecular Docking Analyses Reveal the Bio-Chemical and Molecular Mechanism Underlying the Hypolipidemic Activity of Nano-Liposomal Bioactive Peptides in 3T3-L1 Adipocytes
por: Krobthong, Sucheewin, et al.
Publicado: (2023)

Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy
por: Venkatraman, Simran, et al.
Publicado: (2020)

Role of mTOR inhibitor in cholangiocarcinoma cell progression
por: MOOLTHIYA, PENPAK, et al.
Publicado: (2014)

Downregulation of ABCA1 and ABCG1 transporters by simvastatin in cholangiocarcinoma cells
por: Seeree, Pattaya, et al.
Publicado: (2019)

CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2
por: LEELAWAT, KAWIN, et al.
Publicado: (2013)

Novel Serum Biomarkers to Differentiate Cholangiocarcinoma from Benign Biliary Tract Diseases Using a Proteomic Approach
por: Janvilisri, Tavan, et al.
Publicado: (2015)

Antibacterial efficacy of Citrus hystrix (makrut lime) essential oil against clinical multidrug-resistant methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates
por: Sreepian, Preeyaporn M., et al.
Publicado: (2023)

Dysregulation of microRNA in cholangiocarcinoma identified through a meta-analysis of microRNA profiling
por: Likhitrattanapisal, Somsak, et al.
Publicado: (2020)

Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
por: Akara-amornthum, Perawatt, et al.
Publicado: (2020)

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma
por: Kong, Yang, et al.
Publicado: (2019)

Proteomics dataset for the analysis of the effects of Grammatophyllum speciosum extracts on RAW 264.7 cells
por: Yingchutrakul, Yodying, et al.
Publicado: (2023)

Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression
por: Zou, Yang, et al.
Publicado: (2020)

A Proteome Reference Map of the Causative Agent of Melioidosis Burkholderia pseudomallei
por: Wongtrakoongate, Patompon, et al.
Publicado: (2011)

Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes
por: Wongtrakoongate, Patompon, et al.
Publicado: (2015)

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia
por: Aloud, Amal A., et al.
Publicado: (2018)

Galangin, a natural flavonoid reduces mitochondrial oxidative damage in streptozotocin-induced diabetic rats
por: Aloud, Amal A., et al.
Publicado: (2017)

Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma
por: Lomphithak, Thanpisit, et al.
Publicado: (2020)

MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects
por: Deng, Xu, et al.
Publicado: (2021)

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor
por: Ciolino, H P, et al.
Publicado: (1999)

STELLA Facilitates Differentiation of Germ Cell and Endodermal Lineages of Human Embryonic Stem Cells
por: Wongtrakoongate, Patompon, et al.
Publicado: (2013)

SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity
por: Aiewsakun, Pakorn, et al.
Publicado: (2021)

Proteomic Analysis Reveals Distinct Protein Corona Compositions of Citrate- and Riboflavin-Coated SPIONs
por: Mekseriwattana, Wid, et al.
Publicado: (2022)

Genome-Wide Transcriptional Regulation of the Long Non-coding RNA Steroid Receptor RNA Activator in Human Erythroblasts
por: Sawaengdee, Waritta, et al.
Publicado: (2020)

Galangin, a Flavonoid from Lesser Galangal, Induced Apoptosis via p53-Dependent Pathway in Ovarian Cancer Cells
por: Huang, Haizhi, et al.
Publicado: (2020)

Molecular Changes in Opisthorchis viverrini (Southeast Asian Liver Fluke) during the Transition from the Juvenile to the Adult Stage
por: Jex, Aaron R., et al.
Publicado: (2012)

Salivary proteomics of canine oral tumors using MALDI-TOF mass spectrometry and LC-tandem mass spectrometry
por: Ploypetch, Sekkarin, et al.
Publicado: (2019)

Proteomic profiles of unilateral cryptorchidism in pigs at different ages using MALDI-TOF mass spectrometry and in-gel digestion coupled with mass spectrometry (GeLC-MS/MS) approaches
por: Yimpring, Nathamon, et al.
Publicado: (2020)

Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.)
por: Wongkaewkhiaw, Saharut, et al.
Publicado: (2022)

Identification and Characterization of a Potential Antimicrobial Peptide Isolated from Soil Brevibacillus sp. WUL10 and Its Activity against MRSA Pathogens
por: Atipairin, Apichart, et al.
Publicado: (2022)

Proteomic Response of Aedes aegypti Larvae to Silver/Silver Chloride Nanoparticles Synthesized Using Bacillus thuringiensis subsp. israelensis Metabolites
por: Chimkhan, Nantipat, et al.
Publicado: (2022)

Potential of Arabica Coffee Beans from Northern Thailand: Exploring Antidiabetic Metabolites through Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS) Metabolomic Profiling across Diverse Postharvest Processing Techniques
por: Tantapakul, Cholpisut, et al.
Publicado: (2023)

Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway: Galangin mitigates glucocorticoid-induced osteoporosis
por: Zeng, Chenying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eg7i8jjho9n5mjloa4cn0j8an5