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Absolute configuration, stability, and interconversion of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine valine adducts and their phenylthiohydantoin derivatives

Pyrrolizidine alkaloid-containing plants are widespread in the world and probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolic activation to form dehydropyrrolizidine alkaloids that bind to cellular proteins and DNA leading to...

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Detalles Bibliográficos
Autores principales: Jiang, Xiao, Wang, Shuguang, Zhao, Yuewei, Xia, Qingsu, Cai, Lining, Sun, Xin, Fu, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351779/
https://www.ncbi.nlm.nih.gov/pubmed/28911388
http://dx.doi.org/10.1016/j.jfda.2015.01.004