A Combined Factor V and Factor VIII Deficiency: A Case Report

Factor V and VIII deficiency (F5F8D) is a rare coagulopathy; it’s an autosomal recessive condition. This case report is about of 15-year-old unmarried Saudi female, who presented with a complaint of pain in the lower abdomen. Complete blood count and coagulation profile revealed low hemoglobin and prolongation of activated partial thromboplastin time (aPTT), prothrombin time (PT), and international normalized ratio (INR). The deficiency of factor V and factor VIII was confirmed with factor test revealing reduced activities of factor V and VIII Combined deficiency of factors V and VIII should be considered in differential diagnoses of patients with prolonged INR, PT, and aPTT. Medical management is reserved for those who present with significant bleeding.