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The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway

The study aimed to evaluate the clinical significance of thyroid hormone-responsive (THRSP) and explore its relevant pathways in thyroid carcinoma (THCA). The gene expression data of THRSP were obtained and the prognostic significance of THRSP in THCA was analyzed through various bioinformatics data...

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Autores principales: Yu, Zhen-xing, Xiang, Cheng, Xu, Sheng-gui, Zhang, Yang-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351852/
https://www.ncbi.nlm.nih.gov/pubmed/35945747
http://dx.doi.org/10.1097/MD.0000000000029972
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author Yu, Zhen-xing
Xiang, Cheng
Xu, Sheng-gui
Zhang, Yang-ping
author_facet Yu, Zhen-xing
Xiang, Cheng
Xu, Sheng-gui
Zhang, Yang-ping
author_sort Yu, Zhen-xing
collection PubMed
description The study aimed to evaluate the clinical significance of thyroid hormone-responsive (THRSP) and explore its relevant pathways in thyroid carcinoma (THCA). The gene expression data of THRSP were obtained and the prognostic significance of THRSP in THCA was analyzed through various bioinformatics databases. Then, the factors influencing THRSP mRNA expression were explored, and the function of THRSP in predicting the lymph node metastasis (LNM) stage was determined. We further performed the enrichment analysis and constructed a protein–protein interaction (PPI) network to examine potential regulatory pathways associated with THRSP. THRSP gene expression was significantly increased in THCA compared with the normal tissues. High THRSP mRNA expression had a favorable overall survival (OS) in THCA patients (P < .05). Additionally, the mRNA expression of THRSP was related to stage, histological subtype, and methylation among THCA patients (all P < .05). Besides, THRSP served as a potent predictor in discriminating the LNM stage of thyroid cancer patients. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA) on THRSP-associated genes, THRSP was positively related to metabolic pathways. The upregulation of THRSP predicted a good OS in THCA patients. Furthermore, THRSP might inhibit THCA progression through positive regulation of metabolism-associated pathways.
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spelling pubmed-93518522022-08-05 The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway Yu, Zhen-xing Xiang, Cheng Xu, Sheng-gui Zhang, Yang-ping Medicine (Baltimore) Research Article The study aimed to evaluate the clinical significance of thyroid hormone-responsive (THRSP) and explore its relevant pathways in thyroid carcinoma (THCA). The gene expression data of THRSP were obtained and the prognostic significance of THRSP in THCA was analyzed through various bioinformatics databases. Then, the factors influencing THRSP mRNA expression were explored, and the function of THRSP in predicting the lymph node metastasis (LNM) stage was determined. We further performed the enrichment analysis and constructed a protein–protein interaction (PPI) network to examine potential regulatory pathways associated with THRSP. THRSP gene expression was significantly increased in THCA compared with the normal tissues. High THRSP mRNA expression had a favorable overall survival (OS) in THCA patients (P < .05). Additionally, the mRNA expression of THRSP was related to stage, histological subtype, and methylation among THCA patients (all P < .05). Besides, THRSP served as a potent predictor in discriminating the LNM stage of thyroid cancer patients. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA) on THRSP-associated genes, THRSP was positively related to metabolic pathways. The upregulation of THRSP predicted a good OS in THCA patients. Furthermore, THRSP might inhibit THCA progression through positive regulation of metabolism-associated pathways. Lippincott Williams & Wilkins 2022-08-05 /pmc/articles/PMC9351852/ /pubmed/35945747 http://dx.doi.org/10.1097/MD.0000000000029972 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Zhen-xing
Xiang, Cheng
Xu, Sheng-gui
Zhang, Yang-ping
The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
title The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
title_full The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
title_fullStr The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
title_full_unstemmed The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
title_short The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
title_sort clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351852/
https://www.ncbi.nlm.nih.gov/pubmed/35945747
http://dx.doi.org/10.1097/MD.0000000000029972
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