Cargando…
The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway
The study aimed to evaluate the clinical significance of thyroid hormone-responsive (THRSP) and explore its relevant pathways in thyroid carcinoma (THCA). The gene expression data of THRSP were obtained and the prognostic significance of THRSP in THCA was analyzed through various bioinformatics data...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351852/ https://www.ncbi.nlm.nih.gov/pubmed/35945747 http://dx.doi.org/10.1097/MD.0000000000029972 |
_version_ | 1784762521344802816 |
---|---|
author | Yu, Zhen-xing Xiang, Cheng Xu, Sheng-gui Zhang, Yang-ping |
author_facet | Yu, Zhen-xing Xiang, Cheng Xu, Sheng-gui Zhang, Yang-ping |
author_sort | Yu, Zhen-xing |
collection | PubMed |
description | The study aimed to evaluate the clinical significance of thyroid hormone-responsive (THRSP) and explore its relevant pathways in thyroid carcinoma (THCA). The gene expression data of THRSP were obtained and the prognostic significance of THRSP in THCA was analyzed through various bioinformatics databases. Then, the factors influencing THRSP mRNA expression were explored, and the function of THRSP in predicting the lymph node metastasis (LNM) stage was determined. We further performed the enrichment analysis and constructed a protein–protein interaction (PPI) network to examine potential regulatory pathways associated with THRSP. THRSP gene expression was significantly increased in THCA compared with the normal tissues. High THRSP mRNA expression had a favorable overall survival (OS) in THCA patients (P < .05). Additionally, the mRNA expression of THRSP was related to stage, histological subtype, and methylation among THCA patients (all P < .05). Besides, THRSP served as a potent predictor in discriminating the LNM stage of thyroid cancer patients. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA) on THRSP-associated genes, THRSP was positively related to metabolic pathways. The upregulation of THRSP predicted a good OS in THCA patients. Furthermore, THRSP might inhibit THCA progression through positive regulation of metabolism-associated pathways. |
format | Online Article Text |
id | pubmed-9351852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-93518522022-08-05 The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway Yu, Zhen-xing Xiang, Cheng Xu, Sheng-gui Zhang, Yang-ping Medicine (Baltimore) Research Article The study aimed to evaluate the clinical significance of thyroid hormone-responsive (THRSP) and explore its relevant pathways in thyroid carcinoma (THCA). The gene expression data of THRSP were obtained and the prognostic significance of THRSP in THCA was analyzed through various bioinformatics databases. Then, the factors influencing THRSP mRNA expression were explored, and the function of THRSP in predicting the lymph node metastasis (LNM) stage was determined. We further performed the enrichment analysis and constructed a protein–protein interaction (PPI) network to examine potential regulatory pathways associated with THRSP. THRSP gene expression was significantly increased in THCA compared with the normal tissues. High THRSP mRNA expression had a favorable overall survival (OS) in THCA patients (P < .05). Additionally, the mRNA expression of THRSP was related to stage, histological subtype, and methylation among THCA patients (all P < .05). Besides, THRSP served as a potent predictor in discriminating the LNM stage of thyroid cancer patients. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA) on THRSP-associated genes, THRSP was positively related to metabolic pathways. The upregulation of THRSP predicted a good OS in THCA patients. Furthermore, THRSP might inhibit THCA progression through positive regulation of metabolism-associated pathways. Lippincott Williams & Wilkins 2022-08-05 /pmc/articles/PMC9351852/ /pubmed/35945747 http://dx.doi.org/10.1097/MD.0000000000029972 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yu, Zhen-xing Xiang, Cheng Xu, Sheng-gui Zhang, Yang-ping The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
title | The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
title_full | The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
title_fullStr | The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
title_full_unstemmed | The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
title_short | The clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
title_sort | clinical significance of thyroid hormone-responsive in thyroid carcinoma and its potential regulatory pathway |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351852/ https://www.ncbi.nlm.nih.gov/pubmed/35945747 http://dx.doi.org/10.1097/MD.0000000000029972 |
work_keys_str_mv | AT yuzhenxing theclinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT xiangcheng theclinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT xushenggui theclinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT zhangyangping theclinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT yuzhenxing clinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT xiangcheng clinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT xushenggui clinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway AT zhangyangping clinicalsignificanceofthyroidhormoneresponsiveinthyroidcarcinomaanditspotentialregulatorypathway |