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Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
Qiju Dihuang pill is one of the common Traditional Chinese Medicine to treat ophthalmic diseases. In vivo studies have suggested that Qiju Dihuang pill can be used for treating glaucoma, and it can also be used clinically to treat cataract patients. However, the bioactive ingredients and the therape...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351859/ https://www.ncbi.nlm.nih.gov/pubmed/35945711 http://dx.doi.org/10.1097/MD.0000000000030033 |
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author | Liu, Fei Tian, Mi |
author_facet | Liu, Fei Tian, Mi |
author_sort | Liu, Fei |
collection | PubMed |
description | Qiju Dihuang pill is one of the common Traditional Chinese Medicine to treat ophthalmic diseases. In vivo studies have suggested that Qiju Dihuang pill can be used for treating glaucoma, and it can also be used clinically to treat cataract patients. However, the bioactive ingredients and the therapeutic mechanism of Qiju Dihuang pill on treating these ophthalmic diseases remained unclear. Presently, a systems pharmacology approach which combines pharmacokinetic screening, targeted fishing, biological function enrichment, network pharmacology, and molecular docking analysis, was employed. A total of 134 active ingredients with 72 corresponding targets are identified from Qiju Dihuang pill. Additionally, 3 core targets including CHRM1, ESR1, and AR are obtained from the ingredients and drug targets network analysis. Besides, gen ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis reveal 3 important biological pathways, that is, calcium signaling pathway, insulin signaling pathway and Vascular endothelial growth factor signaling pathway. In final, a molecular docking model was constructed to study the interaction mechanism between active components and drug targets at the molecular level. All the findings show that Qiju Dihuang pill achieves therapeutic effects on treating ophthalmic diseases by regulating the crucial targets of the compounds in it. This work not only provides insight into the therapeutic mechanism of herbal medicine in the treatment of ophthalmic diseases from a multiscale perspective, but also offers an effective approach for drug discovery and development of Traditional Chinese Medicine. |
format | Online Article Text |
id | pubmed-9351859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-93518592022-08-05 Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology Liu, Fei Tian, Mi Medicine (Baltimore) Research Article Qiju Dihuang pill is one of the common Traditional Chinese Medicine to treat ophthalmic diseases. In vivo studies have suggested that Qiju Dihuang pill can be used for treating glaucoma, and it can also be used clinically to treat cataract patients. However, the bioactive ingredients and the therapeutic mechanism of Qiju Dihuang pill on treating these ophthalmic diseases remained unclear. Presently, a systems pharmacology approach which combines pharmacokinetic screening, targeted fishing, biological function enrichment, network pharmacology, and molecular docking analysis, was employed. A total of 134 active ingredients with 72 corresponding targets are identified from Qiju Dihuang pill. Additionally, 3 core targets including CHRM1, ESR1, and AR are obtained from the ingredients and drug targets network analysis. Besides, gen ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis reveal 3 important biological pathways, that is, calcium signaling pathway, insulin signaling pathway and Vascular endothelial growth factor signaling pathway. In final, a molecular docking model was constructed to study the interaction mechanism between active components and drug targets at the molecular level. All the findings show that Qiju Dihuang pill achieves therapeutic effects on treating ophthalmic diseases by regulating the crucial targets of the compounds in it. This work not only provides insight into the therapeutic mechanism of herbal medicine in the treatment of ophthalmic diseases from a multiscale perspective, but also offers an effective approach for drug discovery and development of Traditional Chinese Medicine. Lippincott Williams & Wilkins 2022-08-05 /pmc/articles/PMC9351859/ /pubmed/35945711 http://dx.doi.org/10.1097/MD.0000000000030033 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Liu, Fei Tian, Mi Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
title | Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
title_full | Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
title_fullStr | Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
title_full_unstemmed | Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
title_short | Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
title_sort | study on the mechanism of qiju dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351859/ https://www.ncbi.nlm.nih.gov/pubmed/35945711 http://dx.doi.org/10.1097/MD.0000000000030033 |
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