Cargando…

Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology

Qiju Dihuang pill is one of the common Traditional Chinese Medicine to treat ophthalmic diseases. In vivo studies have suggested that Qiju Dihuang pill can be used for treating glaucoma, and it can also be used clinically to treat cataract patients. However, the bioactive ingredients and the therape...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Fei, Tian, Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351859/
https://www.ncbi.nlm.nih.gov/pubmed/35945711
http://dx.doi.org/10.1097/MD.0000000000030033
_version_ 1784762523084390400
author Liu, Fei
Tian, Mi
author_facet Liu, Fei
Tian, Mi
author_sort Liu, Fei
collection PubMed
description Qiju Dihuang pill is one of the common Traditional Chinese Medicine to treat ophthalmic diseases. In vivo studies have suggested that Qiju Dihuang pill can be used for treating glaucoma, and it can also be used clinically to treat cataract patients. However, the bioactive ingredients and the therapeutic mechanism of Qiju Dihuang pill on treating these ophthalmic diseases remained unclear. Presently, a systems pharmacology approach which combines pharmacokinetic screening, targeted fishing, biological function enrichment, network pharmacology, and molecular docking analysis, was employed. A total of 134 active ingredients with 72 corresponding targets are identified from Qiju Dihuang pill. Additionally, 3 core targets including CHRM1, ESR1, and AR are obtained from the ingredients and drug targets network analysis. Besides, gen ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis reveal 3 important biological pathways, that is, calcium signaling pathway, insulin signaling pathway and Vascular endothelial growth factor signaling pathway. In final, a molecular docking model was constructed to study the interaction mechanism between active components and drug targets at the molecular level. All the findings show that Qiju Dihuang pill achieves therapeutic effects on treating ophthalmic diseases by regulating the crucial targets of the compounds in it. This work not only provides insight into the therapeutic mechanism of herbal medicine in the treatment of ophthalmic diseases from a multiscale perspective, but also offers an effective approach for drug discovery and development of Traditional Chinese Medicine.
format Online
Article
Text
id pubmed-9351859
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-93518592022-08-05 Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology Liu, Fei Tian, Mi Medicine (Baltimore) Research Article Qiju Dihuang pill is one of the common Traditional Chinese Medicine to treat ophthalmic diseases. In vivo studies have suggested that Qiju Dihuang pill can be used for treating glaucoma, and it can also be used clinically to treat cataract patients. However, the bioactive ingredients and the therapeutic mechanism of Qiju Dihuang pill on treating these ophthalmic diseases remained unclear. Presently, a systems pharmacology approach which combines pharmacokinetic screening, targeted fishing, biological function enrichment, network pharmacology, and molecular docking analysis, was employed. A total of 134 active ingredients with 72 corresponding targets are identified from Qiju Dihuang pill. Additionally, 3 core targets including CHRM1, ESR1, and AR are obtained from the ingredients and drug targets network analysis. Besides, gen ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis reveal 3 important biological pathways, that is, calcium signaling pathway, insulin signaling pathway and Vascular endothelial growth factor signaling pathway. In final, a molecular docking model was constructed to study the interaction mechanism between active components and drug targets at the molecular level. All the findings show that Qiju Dihuang pill achieves therapeutic effects on treating ophthalmic diseases by regulating the crucial targets of the compounds in it. This work not only provides insight into the therapeutic mechanism of herbal medicine in the treatment of ophthalmic diseases from a multiscale perspective, but also offers an effective approach for drug discovery and development of Traditional Chinese Medicine. Lippincott Williams & Wilkins 2022-08-05 /pmc/articles/PMC9351859/ /pubmed/35945711 http://dx.doi.org/10.1097/MD.0000000000030033 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Liu, Fei
Tian, Mi
Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
title Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
title_full Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
title_fullStr Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
title_full_unstemmed Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
title_short Study on the mechanism of Qiju Dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
title_sort study on the mechanism of qiju dihuang pill in the treatment of ophthalmic diseases based on systems pharmacology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351859/
https://www.ncbi.nlm.nih.gov/pubmed/35945711
http://dx.doi.org/10.1097/MD.0000000000030033
work_keys_str_mv AT liufei studyonthemechanismofqijudihuangpillinthetreatmentofophthalmicdiseasesbasedonsystemspharmacology
AT tianmi studyonthemechanismofqijudihuangpillinthetreatmentofophthalmicdiseasesbasedonsystemspharmacology