The correlation of BTLA rs1982809 polymorphism with cancer susceptibility: A meta-analysis of 8634 participators

BACKGROUND: The connection between B and T lymphocyte attenuator rs1982809 polymorphism and cancer risk has been investigated by several studies and yielded different results. Therefore, we adopted the meta-analysis method to assess the association of rs1982809 polymorphism with the susceptibility of cancers synthetically. METHODS: Eligible publications were gathered by retrieving PubMed, Web of Science, Embase, Wan Fang, and China National Knowledge Infrastructure. We utilized odds ratio (OR) and 95% confidence intervals (95% CI) to assess correlation intensity and performed subgroup analyses, sensitivity analyses, and publication bias assessments. RESULTS: Six researches that encompassed 3678 cases and 4866 controls were incorporated into our meta-analysis. The rs1982809 polymorphism was proved to be connected with cancer risk by the meta-analysis in the additive model (G vs A: OR = 1.11, 95% CI = 1.04–1.19, P(heterogeneity) = .096). Subgroup analyses revealed that this SNP is regarded as a susceptible factor for cancers in the dominant, heterozygous, and additive model (AG + GG vs AA: OR = 1.46, 95% CI = 1.19–1.80, P(heterogeneity) = .592; AG vs AA: OR = 1.47, 95% CI = 1.19–1.82, P(heterogeneity) = .536; G vs A: OR = 1.32, 95% CI = 1.12–1.55, P(heterogeneity) = .745) in Caucasians; And this SNP may increase the susceptibility to lung cancer (GG vs AG+AA: OR = 1.20, CI = 1.01–1.44, P(heterogeneity) = .854; G vs A: OR = 1.17, CI = 1.02–1.33, P(heterogeneity) = .232). CONCLUSION: The paper concludes that B and T lymphocyte attenuator rs1982809 polymorphism may contribute to cancers, especially in Caucasians, and it may associate with lung cancer.