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A model for the intrinsic limit of cancer therapy: Duality of treatment-induced cell death and treatment-induced stemness
Intratumor cellular heterogeneity and non-genetic cell plasticity in tumors pose a recently recognized challenge to cancer treatment. Because of the dispersion of initial cell states within a clonal tumor cell population, a perturbation imparted by a cytocidal drug only kills a fraction of cells. Du...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352192/ https://www.ncbi.nlm.nih.gov/pubmed/35877695 http://dx.doi.org/10.1371/journal.pcbi.1010319 |