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IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-independent CD4 T cell based control of M. tuberculosis infection has been demonstrated in vivo it is unclear whether...

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Detalles Bibliográficos
Autores principales:	Van Dis, Erik, Fox, Douglas M., Morrison, Huntly M., Fines, Daniel M., Babirye, Janet Peace, McCann, Lily H., Rawal, Sagar, Cox, Jeffery S., Stanley, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352196/ https://www.ncbi.nlm.nih.gov/pubmed/35877763 http://dx.doi.org/10.1371/journal.ppat.1010721

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