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Motor defects in a Drosophila model for spinal muscular atrophy result from SMN depletion during early neurogenesis

Spinal muscular atrophy (SMA) is the most common autosomal recessive neurodegenerative disease, and is characterised by spinal motor neuron loss, impaired motor function and, often, premature death. Mutations and deletions in the widely expressed survival motor neuron 1 (SMN1) gene cause SMA; howeve...

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Detalles Bibliográficos
Autores principales: Grice, Stuart J., Liu, Ji-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352204/
https://www.ncbi.nlm.nih.gov/pubmed/35877682
http://dx.doi.org/10.1371/journal.pgen.1010325

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