Cargando…

Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: In Vitro, In Vivo, and Computational Studies

[Image: see text] Alzheimer’s disease is the most common progressive neurodegenerative mental disorder associated with loss of memory, decline in cognitive function, and dysfunction of language. The prominent pathogenic causes of this disease involve deposition of amyloid-β plaques, acetylcholine ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waseem, Wajeeha, Anwar, Fareeha, Saleem, Uzma, Ahmad, Bashir, Zafar, Rehman, Anwar, Asifa, Saeed Jan, Muhammad, Rashid, Umer, Sadiq, Abdul, Ismail, Tariq
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352245/ https://www.ncbi.nlm.nih.gov/pubmed/35936440 http://dx.doi.org/10.1021/acsomega.2c03058

Ejemplares similares

Inhibition of Valproic Acid-Induced Prenatal Developmental Abnormalities with Antioxidants in Rats
por: Saeed, Mamoona, et al.
Publicado: (2020)

Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer's Disease: Synthesis, Characterization, Computational and in vitro Approaches
por: Zafar, Rehman, et al.
Publicado: (2021)

In Silico Study and Pharmacological Evaluation of Eplerinone as an Anti-Alzheimer’s Drug in STZ-Induced Alzheimer’s Disease Model
por: Hira, Sundas, et al.
Publicado: (2020)

Toxicological Screening of 4-Phenyl-3,4-dihydrobenzo[h]quinolin-2(1H)-one: A New Potential Candidate for Alzheimer’s Treatment
por: Anwar, Fareeha, et al.
Publicado: (2021)

Acute Oral, Subacute, and Developmental Toxicity Profiling of Naphthalene 2-Yl, 2-Chloro, 5-Nitrobenzoate: Assessment Based on Stress Response, Toxicity, and Adverse Outcome Pathways
por: Anwar, Fareeha, et al.
Publicado: (2022)

Experimental and Computational Studies to Characterize and Evaluate the Therapeutic Effect of Albizia lebbeck (L.) Seeds in Alzheimer’s Disease
por: Saleem, Uzma, et al.
Publicado: (2019)

Parkinsonism Attenuation by Antihistamines via Downregulating the Oxidative Stress, Histamine, and Inflammation
por: Ayaz, Maira, et al.
Publicado: (2022)

Anti-arthritic and toxicological evaluation of ethanolic extract of Alternanthera bettzickiana in rats
por: Manan, Maria, et al.
Publicado: (2022)

Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice
por: Hira, Sundas, et al.
Publicado: (2018)

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease
por: Hira, Sundas, et al.
Publicado: (2019)

Antidiabetic effects of Brugmansia aurea leaf extract by modulating the glucose levels, insulin resistance, and oxidative stress mechanism
por: Fatima, Nisar, et al.
Publicado: (2022)

Triazine Derivative as Putative Candidate for the Reduction of Hormone-Positive Breast Tumor: In Silico, Pharmacological, and Toxicological Approach
por: Tayyab Imtiaz, Muhammad, et al.
Publicado: (2021)

Toxicity Evaluation of the Naphthalen-2-yl 3,5-Dinitrobenzoate: A Drug Candidate for Alzheimer Disease
por: Anwar, Fareeha, et al.
Publicado: (2021)

Lawsonia Inermis Markedly Improves Cognitive Functions in Animal Models and Modulate Oxidative Stress Markers in the Brain
por: Mir, Numra Tariq, et al.
Publicado: (2019)

Effect of Venlafaxine, Pramipexole, and Valsartan on Spermatogenesis in Male Rats
por: Saleem, Uzma, et al.
Publicado: (2020)

Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson’s disease
por: Saleem, Uzma, et al.
Publicado: (2019)

Inhibition of Oxidative Stress and the NF-κB Pathway by a Vitamin E Derivative: Pharmacological Approach against Parkinson’s Disease
por: Iqbal, Afshan, et al.
Publicado: (2022)

Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model
por: Saleem, Uzma, et al.
Publicado: (2022)

Acute oral toxicity evaluation of aqueous ethanolic extract of Saccharum munja Roxb. roots in albino mice as per OECD 425 TG
por: Saleem, Uzma, et al.
Publicado: (2017)

Wound Healing Potential and In Silico Appraisal of Convolvulus arvensis L. Methanolic Extract
por: Saleem, Uzma, et al.
Publicado: (2022)

Kaempferol Facilitated Extinction Learning in Contextual Fear Conditioned Rats via Inhibition of Fatty-Acid Amide Hydrolase
por: Ahmad, Hammad, et al.
Publicado: (2020)

Pharmacological Screening of Viola odorata L. for Memory-Enhancing Effect via Modulation of Oxidative Stress and Inflammatory Biomarkers
por: Saleem, Uzma, et al.
Publicado: (2021)

Chemical Characterization, Analgesic, Antioxidant, and Anticholinesterase Potentials of Essential Oils From Isodon rugosus Wall. ex. Benth
por: Sadiq, Abdul, et al.
Publicado: (2018)

Antioxidant Molecules Isolated from Edible Prostrate Knotweed: Rational Derivatization to Produce More Potent Molecules
por: Mahnashi, Mater H., et al.
Publicado: (2022)

Diuretic Potential of Fenchyl Acetate with Its Mechanism of Action: Toxicity Study
por: Bashir, Asifa, et al.
Publicado: (2023)

Phytochemical and toxicological evaluation of Zephyranthes citrina
por: Rehman, Muhammad Haseeb Ur, et al.
Publicado: (2022)

E-Learning amid the COVID-19 Lockdown: Standpoint of Medical and Dental Undergraduates
por: Anwar, Aiza, et al.
Publicado: (2021)

Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds
por: Haider, Asfia, et al.
Publicado: (2020)

Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies
por: Javed, Muhammad Aamir, et al.
Publicado: (2022)

An Optimized Hyperparameter of Convolutional Neural Network Algorithm for Bug Severity Prediction in Alzheimer's-Based IoT System
por: Yousaf, Iqra, et al.
Publicado: (2022)

In vitro anti-inflammatory, antidiabetic, antibacterial, and in silico studies of Ferruginan A isolated from Olea ferruginea Royle (Oleaceae)
por: Rauf, Abdur, et al.
Publicado: (2023)

Toward the Noninvasive Diagnosis of Alzheimer’s Disease: Molecular Basis for the Specificity of Curcumin for Fibrillar Amyloid-β
por: Khurshid, Beenish, et al.
Publicado: (2022)

Analytical Investigation of the Time-Dependent Stagnation Point Flow of a CNT Nanofluid over a Stretching Surface
por: Rehman, Ali, et al.
Publicado: (2022)

Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile
por: Zaidi, Amber, et al.
Publicado: (2023)

Comparison of Intralesional Meglumine Antimonite along with oral Itraconazole to Intralesional Meglumine Antimonite in the treatment of Cutaneous Leishmaniasis
por: Bashir, Uzma, et al.
Publicado: (2019)

Green Synthesis of Silver Nanoparticles through Reduction with Solanum xanthocarpum L. Berry Extract: Characterization, Antimicrobial and Urease Inhibitory Activities against Helicobacter pylori
por: Amin, Muhammad, et al.
Publicado: (2012)

Numerical analysis of slip-enhanced flow over a curved surface with magnetized water-based hybrid nanofluid containing gyrotactic microorganisms
por: Yasmin, Humaira, et al.
Publicado: (2023)

Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts
por: Akhtar, Muhammad Furqan, et al.
Publicado: (2022)

Nutritional probing and storage stability of papaya jam supplemented with date pit powder
por: Anwar, Shafaq, et al.
Publicado: (2023)

Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of atriplex laciniata L.: potential effectiveness in Alzheimer’s and other neurological disorders
por: Kamal, Zul, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ns5lad08348qvqfg293io93p36