Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds

[Image: see text] The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated. The use of a second-generation MacMillan catalyst as hydrochloride salt consistently accelerate...

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Detalles Bibliográficos
Autores principales: Corbisiero, Dario, Fantoni, Tommaso, Ferrazzano, Lucia, Martelli, Giulia, Cantelmi, Paolo, Mattellone, Alexia, Palladino, Chiara, Monari, Magda, Pedrazzani, Riccardo, Tolomelli, Alessandra, Cabri, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352246/
https://www.ncbi.nlm.nih.gov/pubmed/35936453
http://dx.doi.org/10.1021/acsomega.2c03477

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