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Malakoplakia of the appendix in a young healthy adult: a case report and literature review
Malakoplakia is a rare entity on inflammatory base that mostly occurs in immunocompromised individuals which is thought to be secondary to a bactericidal defect in macrophages. The genitourinary tract is typically affected. The appendix is a very rare localization. We report a case of malakoplakia i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352265/ https://www.ncbi.nlm.nih.gov/pubmed/35935467 http://dx.doi.org/10.1093/jscr/rjac357 |
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author | Pastena, Dario Giambusso, Mauro Castri, Federica Potenza, Angelo Eugenio Caprino, Paola Sacchetti, Franco Sofo, Luigi |
author_facet | Pastena, Dario Giambusso, Mauro Castri, Federica Potenza, Angelo Eugenio Caprino, Paola Sacchetti, Franco Sofo, Luigi |
author_sort | Pastena, Dario |
collection | PubMed |
description | Malakoplakia is a rare entity on inflammatory base that mostly occurs in immunocompromised individuals which is thought to be secondary to a bactericidal defect in macrophages. The genitourinary tract is typically affected. The appendix is a very rare localization. We report a case of malakoplakia in the appendix of a young healthy patient with a recent history of abdominal pain associated with diarrhea and nausea. The colonscopy and CT scan showed an extramucosal bumping mass pressing on the cecum and covered by normal mucosa. The patient underwent to laparoscopic appendectomy. The histology showed a malakoplakia of the appendix. Gastrointestinal localization of malakoplakia is often associated with preexisting diseases, which are probably responsible for an immune disorder underlying the etiopathogenesis of the disease. However, in our case, the patient had no comorbidities. Probably, a clinically unknown immune predisposition plays an important role. Further studies are needed to clarify this nexus. |
format | Online Article Text |
id | pubmed-9352265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-93522652022-08-05 Malakoplakia of the appendix in a young healthy adult: a case report and literature review Pastena, Dario Giambusso, Mauro Castri, Federica Potenza, Angelo Eugenio Caprino, Paola Sacchetti, Franco Sofo, Luigi J Surg Case Rep Case Report Malakoplakia is a rare entity on inflammatory base that mostly occurs in immunocompromised individuals which is thought to be secondary to a bactericidal defect in macrophages. The genitourinary tract is typically affected. The appendix is a very rare localization. We report a case of malakoplakia in the appendix of a young healthy patient with a recent history of abdominal pain associated with diarrhea and nausea. The colonscopy and CT scan showed an extramucosal bumping mass pressing on the cecum and covered by normal mucosa. The patient underwent to laparoscopic appendectomy. The histology showed a malakoplakia of the appendix. Gastrointestinal localization of malakoplakia is often associated with preexisting diseases, which are probably responsible for an immune disorder underlying the etiopathogenesis of the disease. However, in our case, the patient had no comorbidities. Probably, a clinically unknown immune predisposition plays an important role. Further studies are needed to clarify this nexus. Oxford University Press 2022-08-04 /pmc/articles/PMC9352265/ /pubmed/35935467 http://dx.doi.org/10.1093/jscr/rjac357 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Pastena, Dario Giambusso, Mauro Castri, Federica Potenza, Angelo Eugenio Caprino, Paola Sacchetti, Franco Sofo, Luigi Malakoplakia of the appendix in a young healthy adult: a case report and literature review |
title | Malakoplakia of the appendix in a young healthy adult: a case report and literature review |
title_full | Malakoplakia of the appendix in a young healthy adult: a case report and literature review |
title_fullStr | Malakoplakia of the appendix in a young healthy adult: a case report and literature review |
title_full_unstemmed | Malakoplakia of the appendix in a young healthy adult: a case report and literature review |
title_short | Malakoplakia of the appendix in a young healthy adult: a case report and literature review |
title_sort | malakoplakia of the appendix in a young healthy adult: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352265/ https://www.ncbi.nlm.nih.gov/pubmed/35935467 http://dx.doi.org/10.1093/jscr/rjac357 |
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