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Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP(+)-Dependent Malic Enzyme 1

[Image: see text] NADP(+)-dependent malic enzyme 1 (ME1) decarboxylates malate to form pyruvate and NADPH in the cytoplasm, where it mediates diverse biological functions related to the generation of lipids and other cellular building blocks. As such, ME1 has been implicated in the progression of ca...

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Detalles Bibliográficos
Autores principales:	Yoshida, Tomohiro, Kawabe, Tetsuhiro, Cantley, Lewis C., Lyssiotis, Costas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352307/ https://www.ncbi.nlm.nih.gov/pubmed/35819845 http://dx.doi.org/10.1021/acs.biochem.2c00123

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