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CD4+ T-Cell Epitope Prediction by Combined Analysis of Antigen Conformational Flexibility and Peptide-MHCII Binding Affinity

[Image: see text] Antigen processing in the class II MHC pathway depends on conventional proteolytic enzymes, potentially acting on antigens in native-like conformational states. CD4+ epitope dominance arises from a competition among antigen folding, proteolysis, and MHCII binding. Protease-sensitiv...

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Detalles Bibliográficos
Autores principales:	Charles, Tysheena, Moss, Daniel L., Bhat, Pawan, Moore, Peyton W., Kummer, Nicholas A., Bhattacharya, Avik, Landry, Samuel J., Mettu, Ramgopal R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352311/ https://www.ncbi.nlm.nih.gov/pubmed/35834502 http://dx.doi.org/10.1021/acs.biochem.2c00237

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