Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease

[Image: see text] The abnormal phosphorylation of the τ-protein is a typical early pathological feature of Alzheimer’s disease (AD). The excessive phosphorylation of the τ-protein in the brain causes the formation of neurofibrillary tangles (NFTs) and increases the neurotoxicity of amyloid-β (Aβ). T...

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Detalles Bibliográficos
Autores principales: Liang, Meihao, Gu, Lili, Zhang, Hongjie, Min, Jingli, Wang, Zunyuan, Ma, Zhen, Zhang, Chixiao, Zeng, Shenxin, Pan, Youlu, Yan, Dongmei, Shen, Zhengrong, Huang, Wenhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352321/
https://www.ncbi.nlm.nih.gov/pubmed/35936449
http://dx.doi.org/10.1021/acsomega.2c02130

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