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Development, Molecular Docking, and In Silico ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications via Suppression of the Polyol Pathway

[Image: see text] Diabetic complications are associated with overexpression of aldose reductase, an enzyme that catalyzes the first step of the polyol pathway. Osmotic stress in the hyperglycemic state is linked with the intracellular accumulation of sorbitol along with the depletion of NADPH and ev...

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Detalles Bibliográficos
Autores principales:	Imran, Aqeel, Shehzad, Muhammad Tariq, Shah, Syed Jawad Ali, Laws, Mark, al-Adhami, Taha, Rahman, Khondaker Miraz, Khan, Imtiaz Ali, Shafiq, Zahid, Iqbal, Jamshed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352332/ https://www.ncbi.nlm.nih.gov/pubmed/35936488 http://dx.doi.org/10.1021/acsomega.2c02326

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